NDLI: Role and regulation of EGFR in actin remodeling in sperm capacitation and the acrosome reaction

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Breitbart, Haim Etkovitz, Nir
Description	Country affiliation: Israel Author Affiliation: Breitbart H ( The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel. breith@mail.biu.ac.il)
Abstract	To bind and fertilize the egg, the spermatozoon should undergo few biochemical and motility changes in the female reproductive tract collectively called capacitation. The capacitated spermatozoon binds to the egg zona pellucida, and then undergoes the acrosome reaction (AR), which allows its penetration into the egg. The mechanisms regulating sperm capacitation and the AR are not completely understood. In the present review, we summarize some data regarding the role and regulation of the epidermal growth factor receptor (EGFR) in these processes. In the capacitation process, the EGFR is partially activated by protein kinase A (PKA), resulting in phospholipase D (PLD) activation and actin polymerization. Protein kinase C alpha (PKCα), which is already activated at the beginning of the capacitation, also participates in PLD activation. Further activation of the EGFR at the end of the capacitation enhances intracellular $Ca^{2+}$ concentration leading to F-actin breakdown and allows the AR to take place. Under in vivo conditions, the EGFR can be directly activated by its known ligand epidermal growth factor (EGF), and indirectly by activating PKA or by transactivation mediated by G protein-coupled receptors (GPCRs) activation or by ouabain. Under physiological conditions, sperm PKA is activated mainly by bicarbonate, which activates the soluble adenylyl cyclase to produce cyclic adenosine monophosphate (cAMP), the activator of PKA. The GPCR activators angiotensin II or lysophosphatidic acid, as well as ouabain and EGF are physiological components present in the female reproductive tract.
File Format	HTM / HTML
ISSN	1008682X
e-ISSN	17457262
DOI	10.1038/aja.2010.78
Journal	Asian Journal of Andrology
Issue Number	1
Volume Number	13
Language	English
Publisher	Wolters Kluwer - Medknow
Publisher Date	2011-01-01
Publisher Place	China
Access Restriction	Open
Subject Keyword	Discipline Urology Acrosome Reaction Physiology Actins Metabolism Receptor, Epidermal Growth Factor Sperm Capacitation Spermatozoa Animals Cyclic Amp-dependent Protein Kinases Phosphatidylinositol 3-kinases Protein Kinase C Signal Transduction
Content Type	Text
Resource Type	Article
Subject	Urology

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