NDLI: Prostate cancer risk and aggressiveness associated with the CYP1B1 4326C/G (Leu432Val) polymorphism: a meta-analysis of 2788 cases and 2968 controls.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yang, Jie Xu, Dong-Liang Lu, Qiang Han, Zhi-Jian Tao, Jun Lu, Pei Wang, Chao Di, Xiao-Ke Gu, Min
Description	Country affiliation: China Author Affiliation: Yang J ( Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.)
Abstract	To derive a precise estimation of the associations between the cytochrome P450 1B1 (CYP1B1) 4326C/G variants and prostate cancer (PCa) risk or aggressiveness, a meta-analysis was performed using all eligible published studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the association in seven literature studies with 2788 cases and 2968 controls. In the overall analysis, no significant association was found between the CYP1B1 4326C/G polymorphism and PCa risk, but ethnicity subgroup analyses and a case-source analysis revealed significant associations. The 4326G allele showed a significant association with increased PCa risk in Asians (OR=1.52, 95% CI: 1.20-1.92), and significant associations were also observed in a heterozygote comparison (OR=1.40, 95% CI: 1.03-1.89), a homozygote comparison (OR=2.38, 95% CI: 1.31-4.33) and in a dominant genetic model (OR=1.52, 95% CI: 1.14-2.01). Moreover, the 4326G allele was also significantly correlated with an increased risk of sporadic PCa (OR=1.13, 95% CI: 1.04-1.24), and significant associations were observed in a heterozygote comparison (OR=1.16, 95% CI: 1.02-1.33), a homozygote comparison (OR=1.24, 95% CI: 1.03-1.49) and a dominant genetic model (OR=1.19, 95% CI: 1.05-1.34). The overall analyses and all subgroup analyses showed no significant association between the 4326C/G polymorphism and PCa aggressiveness. Our meta-analysis showed that CYP1B1 4326G allele is significantly associated with an increased PCa risk in Asians and in sporadic PCa cases.
File Format	HTM / HTML
ISSN	1008682X
e-ISSN	17457262
DOI	10.1038/aja.2012.4
Journal	Asian Journal of Andrology
Issue Number	4
Volume Number	14
Language	English
Publisher	Wolters Kluwer - Medknow
Publisher Date	2012-07-01
Publisher Place	China
Access Restriction	Open
Subject Keyword	Discipline Urology Aryl Hydrocarbon Hydroxylases Genetics Asian Continental Ancestry Group Prostatic Neoplasms Pathology Alleles Confidence Intervals Cytochrome P-450 Cyp1b1 Heterozygote Homozygote Odds Ratio Polymorphism, Genetic Ethnology Risk Factors Meta-analysis
Content Type	Text
Resource Type	Article
Subject	Urology

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