NDLI: Expression patterns and association analysis of the porcine DHX58 gene.

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Expression patterns and association analysis of the porcine DHX58 gene.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Li, X. Y. Han, C. M. Wang, Y. Liu, H. Z. Wu, Z. F. Gao, Q. H. Zhao, S. H.
Description	Country affiliation: China Author Affiliation: Li XY ( Key Laboratory of Agricultural Animal Genetics, Breeding, and Reproduction, Ministry of Education, Huazhong Agricultural University, Wuhan, Hubei, China.)
Abstract	RIG-1 signalling is responsible for the detection of cytoplasmic viral RNA molecules. DEXH(Asp-Glu-X-His) box polypeptide 58 (encoded by DHX58) is a negative regulator of the RIG-1 signalling pathway. In human, the DHX58 gene can be upregulated and can inhibit the RIG-1 signalling pathway during viral infection. In this study, porcine DHX58 gene expression patterns were studied. According to our results, the porcine DHX58 gene was upregulated not only by the stimulation of Poly I:C but also by the stimulation of lipopolysaccharides (LPS). One polymorphism (g.4919G>C), detected in the ninth intron,was significantly associated with some blood parameters including the red cell distribution width of 1-day-old pigs and white blood cell counts, lymphocyte absolute counts, and platelet distribution width of 17-day-old pigs (P < 0.05). Moreover, the individuals with the genotype GG have a significantly higher mean white blood cell count than individuals with genotype CC or GC (P < 0.05). Our study indicates that DHX58 is an important gene that is associated with the immune response in swine.
File Format	HTM / HTML
ISSN	02689146
Issue Number	5
Volume Number	41
e-ISSN	13652052
Journal	Animal Genetics
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2010-10-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Genetics Discipline Zoology Polymorphism, Single Nucleotide Rna Helicases Genetics Swine Immunology Animals Gene Expression Lipopolysaccharides Poly I-c Metabolism Signal Transduction Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine Animal Science and Zoology

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