NDLI: Collateral circulation formation determines the characteristic profiles of contrast-enhanced MRI in the infarcted myocardium of pigs.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wang, Jian Xiang, Bo Lin, Hung-yu Liu, Hong-yu Freed, Darren Arora, Rakesh C. Tian, Gang-hong
Description	Author Affiliation: Wang J ( 1] Department of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China [2] National Research Council, Winnipeg, Manitoba, Canada R3B 1Y6 [3] Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitob); Xiang B ( 1] National Research Council, Winnipeg, Manitoba, Canada R3B 1Y6 [2] Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada R3E 3P5.); Lin HY ( National Research Council, Winnipeg, Manitoba, Canada R3B 1Y6.); Liu HY ( Department of Cardiovascular Surgery, the First Affiliated Hospital, Harbin Medical University, Harbin 150001, China.); Freed D ( 1] National Research Council, Winnipeg, Manitoba, Canada R3B 1Y6 [2] Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada R3E 3P5 [3] Cardiac Science Program, Institute of Cardiovascular Science, St Boniface General Hospital, Winnipeg, Manitoba, Canada R2); Arora RC ( 1] National Research Council, Winnipeg, Manitoba, Canada R3B 1Y6 [2] Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada R3E 3P5 [3] Cardiac Science Program, Institute of Cardiovascular Science, St Boniface General Hospital, Winnipeg, Manitoba, Canada R2); Tian GH ( 1] National Research Council, Winnipeg, Manitoba, Canada R3B 1Y6 [2] Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada R3E 3P5.)
Abstract	AIM: To investigate the relationship between the collateral circulation and contrast-enhanced MR signal change for myocardial infarction (MI) in pigs. METHODS: Pigs underwent permanent ligation of two diagonal branches of the left anterior descending artery. First-pass perfusion (FPP) MRI (for detecting myocardial perfusion abnormalities) and delayed enhancement (DE) MRI (for estimating myocardial infarction) using Gd-DTPA were performed at 2 h, 7 d and 4 weeks after the coronary occlusion. Myocardial blood flow (MBF) was evaluated using nonradioactive red-colored microspheres. Histological examination was performed to characterize the infarcts. RESULTS: Acute MI performed at 2 h afterwards was characterized by hypoenhancement in both FPP- and DE-MRI, with small and almost unchanged FPP-signal intensity (SI) and DE-SI due to negligible MBF. Subacute MI detected 7 d afterwards showed small but significantly increaseing FPP-SI, and was visible as a sluggish hyperenhancement in DE-MRI with considerably higher DE-SI compared to the normal myocardium; the MBF approached the half-normal value. Chronic MI detected at 4 weeks afterwards showed increasing FPP-SI comparable to the normal myocardium, and a rapid hyperenhancement in DE-MRI with even higher DE-SI; the MBF was close to the normal value. The MBF was correlated with FPP-SI (r=+0.94, P<0.01) and with the peak DE-SI (r=+0.92, P<0.01) at the three MI stages. Remodeled vessels were observed at intra-infarction and peri-infarction zones during the subacute and chronic periods. CONCLUSION: Progressive collateral recovery determines the characteristic profiles of contrast-enhanced MRI in acute, subacute and chronic myocardial infarction in pigs. The FPP- and DE-MRI signal profiles not only depend on the loss of tissue viability and enlarged interstitial space, but also on establishing a collateral circulation.
File Format	HTM / HTML
ISSN	16714083
e-ISSN	17457254
DOI	10.1038/aps.2014.158
Journal	Acta Pharmacologica Sinica
Issue Number	4
Volume Number	36
Language	English
Publisher	Macmillan Publishers Limited
Publisher Date	2015-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Pharmacology Collateral Circulation Contrast Media Gadolinium Dtpa Myocardial Infarction Pathology Myocardium Animals Swine Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Pharmacology Pharmacology (medical)

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