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Regional differences in HLA antigen and haplotype frequency distributions in Germany and their relevance to the optimization of hematopoietic stem cell donor recruitment.

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Regional differences in HLA antigen and haplotype frequency distributions in Germany and their relevance to the optimization of hematopoietic stem cell donor recruitment.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Schmidt, A. H. Solloch, U. V. Baier, D. Stahr, A. Wassmuth, R. Ehninger, G. Rutt, C.
Spatial Coverage	Germany
Description	Country affiliation: Germany Author Affiliation: Schmidt AH ( DKMS German Bone Marrow Donor Center, Tübingen, Germany. schmidt@dkms.de)
Abstract	We analyzed regional differences in human leukocyte antigen (HLA)-A, -B, and -DR antigen and haplotype frequencies based on a sample of approximately 320,000 German donors in order to identify regions that are especially suited for ongoing stem cell donor recruitment. Geographic partitioning was carried out by postal code regions. Analysis of genetic distances suggests the existence of three regional clusters in South (regions 6-9), East (0-1), and Northwest (2-5) Germany. The southern cluster shows most favorable characteristics with respect to haplotypic and phenotypic diversity and the occurrence of rare HLA antigens. The opposite behavior is shown by regions 2-4 of the northwestern cluster. As a result of lower HLA diversity, completeness of a regional donor file in region 4 with 100,000 donors would be higher than that of a file in region 7 with 170,000 donors. This fact shows the relevance of regional HLA differences for practical donor registry planning. Results such as those presented in this work can be used to diminish the problem of decreasing marginal benefit of donor recruitment, as more than 13 million donors are registered worldwide today.
File Format	HTM / HTML
ISSN	20592302
Issue Number	5
Volume Number	76
e-ISSN	20592310
Journal	Tissue Antigens
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2010-11-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Genetics Discipline Immunology Hla Antigens Genetics Hematopoietic Stem Cell Transplantation Tissue Donors Tissue And Organ Procurement Alleles Female Gene Frequency Genes, Mhc Class I Genes, Mhc Class Ii Germany Hla-a Antigens Hla-b Antigens Hla-dr Antigens Hla-drb1 Chains Haplotypes Heterozygote Humans Male Registries Statistics & Numerical Data Journal Article
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology and Allergy Immunology

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Regional differences in HLA antigen and haplotype frequency distributions in Germany and their relevance to the optimization of hematopoietic stem cell donor recruitment.

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