NDLI: Full-length HLA-DPB1 diversity in multiple alleles of individuals from Caucasian, Black, or Oriental origin.

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Full-length HLA-DPB1 diversity in multiple alleles of individuals from Caucasian, Black, or Oriental origin.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lauterbach, N. Voorter, C. E. M. Stallinga, C. M. H. A. Groeneweg, M. Wieten, L. Tilanus, M. G. J.
Description	Country affiliation: Netherlands Author Affiliation: Lauterbach N ( Department of Transplantation Immunology, Tissue Typing Laboratory, Maastricht University Medical Centre, The Netherlands.)
Abstract	Despite DP antigens have been shown to be stimulators of the mixed lymphocyte reaction, human leukocyte antigen-DPB1 is not considered in the matching criteria for hematopoietic stem cell transplantation (HSCT). The role of DPB1 matching in HSCT remains inconclusive because of contradictory findings in different studies. The concept of permissible and non-permissible mismatches might clarify these contradictory results. Although several groups have attempted to identify immunogenic epitopes in exon 2 to establish permissive and non-permissive allele groups, the direct correlation between individual exon 2 amino acids and epitopes with DPB1 immunogenicity is still not evident. We hypothesize that polymorphism within the entire molecule, including polymorphic variability in different ethnic groups, is crucial to unravel the function of DPB1 polymorphism. Using an RNA-based approach, we sequenced all frequent and available non-frequent DPB1 alleles full length from 148 samples representing 28 different DPB1 alleles from either Black, Caucasian, or Oriental origin. We identified various DPB1 alleles with, in addition to the exon 2 polymorphism, polymorphisms in exons 1, 3, 4, and 5. Based on this polymorphism outside exon 2, we defined one new allele. Two alleles with identical exon 2 polymorphism but differing outside exon 2 were identified in individuals of different ethnic groups. As T cell binding is not restricted to the polymorphic groove and polymorphism in the ß2 domain of the DP molecule affects CD4 interaction, full-length polymorphism should be considered to determine immunogenicity. Eventually, this knowledge will provide new insights in the classification of DPB1 polymorphism and more importantly will add new perspectives to the concept of permissiveness in transplantation.
File Format	HTM / HTML
ISSN	20592302
Issue Number	3
Volume Number	79
e-ISSN	20592310
Journal	Tissue Antigens
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2012-03-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Genetics Discipline Immunology African Continental Ancestry Group Genetics Alleles Asian Continental Ancestry Group European Continental Ancestry Group Exons Genetic Variation Hla-dp Beta-chains Humans Models, Molecular Molecular Sequence Data Polymerase Chain Reaction Polymorphism, Genetic Sequence Alignment Journal Article
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology and Allergy Immunology

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A new polymorphic position in exon 2 shows the novel allele HLA-DPB1*123:01.

Identification of a novel allele, HLA-DPB1*168:01, in a Chinese individual.

Characterization of the novel HLA-DPB1*139:01 allele identified by sequence-based typing in a Chinese Han individual.

A novel HLA-DPB1 allele, DPB1*125:01, identified by sequence-based typing in an Indian individual.

Description of the novel HLA-DPB1*137:01 allele found in an Italian subject.

The new allele HLA-DPB1*363:01 identified by sequence-based typing in a donor from the Chinese Marrow Donor Program.

Characterization of the novel HLA-DPA1*02:05 allele identified by sequence-based typing.

Characterization of the novel HLA-DPB1*140:01 allele identified by sequence-based typing.

Identification of a novel HLA-DPB1 allele, HLA-DPB1*167:01, in a Chinese individual.

Full-length HLA-DPB1 diversity in multiple alleles of individuals from Caucasian, Black, or Oriental origin.

Similar Documents

A new polymorphic position in exon 2 shows the novel allele HLA-DPB1*123:01.

Identification of a novel allele, HLA-DPB1*168:01, in a Chinese individual.

Characterization of the novel HLA-DPB1*139:01 allele identified by sequence-based typing in a Chinese Han individual.

A novel HLA-DPB1 allele, DPB1*125:01, identified by sequence-based typing in an Indian individual.

Description of the novel HLA-DPB1*137:01 allele found in an Italian subject.

The new allele HLA-DPB1*363:01 identified by sequence-based typing in a donor from the Chinese Marrow Donor Program.

Characterization of the novel HLA-DPA1*02:05 allele identified by sequence-based typing.

Characterization of the novel HLA-DPB1*140:01 allele identified by sequence-based typing.

Identification of a novel HLA-DPB1 allele, HLA-DPB1*167:01, in a Chinese individual.

Full-length HLA-DPB1 diversity in multiple alleles of individuals from Caucasian, Black, or Oriental origin.