NDLI: Analysis of lipid transfer activity between model nascent HDL particles and plasma lipoproteins: implications for current concepts of nascent HDL maturation and genesis.

Please wait, while we are loading the content...

Analysis of lipid transfer activity between model nascent HDL particles and plasma lipoproteins: implications for current concepts of nascent HDL maturation and genesis.

CGI-58/ABHD5 is a coenzyme A-dependent lysophosphatidic acid acyltransferase.

Disruption of the C-terminal helix by single amino acid deletion is directly responsible for impaired cholesterol efflux ability of apolipoprotein A-I Nichinan.

Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.

APOC1 T45S polymorphism is associated with reduced obesity indices and lower plasma concentrations of leptin and apolipoprotein C-I in aboriginal Canadians.

Photoactivable sphingosine as a tool to study membrane microenvironments in cultured cells.

Direct quantitative determination of ceramide glycosylation in vivo: a new approach to evaluate cellular enzyme activity of glucosylceramide synthase.

Quantitation of serum angiopoietin-like proteins 3 and 4 in a Finnish population sample.

Baseline cholesterol absorption and the response to ezetimibe/simvastatin therapy: a post-hoc analysis of the ENHANCE trial.

Lipid second messengers and related enzymes in vertebrate rod outer segments.

Glucose stimulates cholesterol 7α-hydroxylase gene transcription in human hepatocytes

Modulation of the activity of cytosolic phospholipase A2α (cPLA2α) by cellular sphingolipids and inhibition of cPLA2α by sphingomyelin

INSIG1 influences obesity-related hypertriglyceridemia in humans.

Liver X receptor activation promotes macrophage-to-feces reverse cholesterol transport in a dyslipidemic hamster model.

Alternative splicing attenuates transgenic expression directed by the apolipoprotein E promoter-enhancer based expression vector pLIV11.

Separation and characterization of cardiolipin molecular species by reverse-phase ion pair high-performance liquid chromatography-mass spectrometry.

Myeloperoxidase and serum amyloid A contribute to impaired in vivo reverse cholesterol transport during the acute phase response but not group IIA secretory phospholipase A(2).

The acute phase response inhibits reverse cholesterol transport.

A novel role for ABCA1-generated large pre-beta migrating nascent HDL in the regulation of hepatic VLDL triglyceride secretion.

In Memoriam: William E. Connor (1921-2009).

Year: 2010 Volume: 51 Issue: 3

Year: 2010 Volume: 51 Issue: 2

Year: 2010 Volume: 51 Issue: 1

Year: 2009 Volume: 50

Year: 2008 Volume: 49

Year: 2007 Volume: 48

Year: 2006 Volume: 47

Year: 2005 Volume: 46

Year: 2004 Volume: 45

Year: 2003 Volume: 44

Year: 2002 Volume: 43

Year: 2001 Volume: 42

Year: 2000 Volume: 41

Year: 1998 Volume: 39

Year: 1990 Volume: 31

Year: 1981 Volume: 22

Analysis of lipid transfer activity between model nascent HDL particles and plasma lipoproteins: implications for current concepts of nascent HDL maturation and genesis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bailey, Dana Ruel, Isabelle Hafiane, Anouar Cochrane, Haley Iatan, Iulia Jauhiainen, Matti Ehnholm, Christian Krimbou, Larbi Genest, Jacques
Description	Country affiliation: Canada Author Affiliation: Bailey D ( Cardiovascular Genetics Laboratory, Cardiology Division, McGill University Health Centre/Royal Victoria Hospital, Québec, Canada.)
Abstract	The specifics of nascent HDL remodeling within the plasma compartment remain poorly understood. We developed an in vitro assay to monitor the lipid transfer between model nascent HDL (LpA-I) and plasma lipoproteins. Incubation of alpha-(125)I-LpA-I with plasma resulted in association of LpA-I with existing plasma HDL, whereas incubation with TD plasma or LDL resulted in conversion of alpha-(125)I-LpA-I to prebeta-HDL. To further investigate the dynamics of lipid transfer, nascent LpA-I were labeled with cell-derived [(3 )H]cholesterol (UC) or [(3)H]phosphatidylcholine (PC) and incubated with plasma at 37 degrees C. The majority of UC and PC were rapidly transferred to apolipoprotein B (apoB). Subsequently, UC was redistributed to HDL for esterification before being returned to apoB. The presence of a phospholipid transfer protein (PLTP) stimulator or purified PLTP promoted PC transfer to apoB. Conversely, PC transfer was abolished in plasma from PLTP(-/-) mice. Injection of (125)I-LpA-I into rabbits resulted in a rapid size redistribution of (125)I-LpA-I. The majority of [(3)H]UC from labeled r(HDL) was esterified in vivo within HDL, whereas a minority was found in LDL. These data suggest that apoB plays a major role in nascent HDL remodeling by accepting their lipids and donating UC to the LCAT reaction. The finding that nascent particles were depleted of their lipids and remodeled in the presence of plasma lipoproteins raises questions about their stability and subsequent interaction with LCAT.
File Format	HTM / HTML
ISSN	00222275
e-ISSN	15397262
DOI	10.1194/jlr.M001875
Journal	The Journal of Lipid Research
Issue Number	4
Volume Number	51
Language	English
Publisher	American Society for Biochemistry and Molecular Biology
Publisher Date	2010-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Biochemistry Apolipoproteins B Physiology High-density Lipoproteins, Pre-beta Chemistry Lipoproteins Animals Apolipoprotein A-i Blood Metabolism Apolipoprotein E3 Cholesterol Cholesterol Ester Transfer Proteins Genetics Esterification Hep G2 Cells Administration & Dosage Isolation & Purification Lipoproteins, Hdl Mice Mice, Knockout Phospholipid Transfer Proteins Rabbits Tangier Disease Time Factors Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Endocrinology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Analysis of lipid transfer activity between model nascent HDL particles and plasma lipoproteins: implications for current concepts of nascent HDL maturation and genesis[S]

Secretion of apolipoprotein B-containing lipoproteins from HeLa cells is dependent on expression of the microsomal triglyceride transfer protein and is regulated by lipid availability.

Defective functionality of HDL particles in familial apoA-I deficiency: relevance of alterations in HDL lipidome and proteome.

Transgenic mouse models of lipoprotein metabolism and atherosclerosis.

Distinct composition of human fetal HDL attenuates its anti-oxidative capacity

Human plasma phospholipid transfer protein specific activity is correlated with HDL size: implications for lipoprotein physiology.

A cholesteryl ester transfer complex in human plasma.

PXR agonism decreases plasma HDL levels in ApoE⁎3-Leiden.CETP mice

CETP does not affect triglyceride production or clearance in APOE*3-Leiden mice.

Analysis of lipid transfer activity between model nascent HDL particles and plasma lipoproteins: implications for current concepts of nascent HDL maturation and genesis.

Similar Documents

Analysis of lipid transfer activity between model nascent HDL particles and plasma lipoproteins: implications for current concepts of nascent HDL maturation and genesis[S]

Secretion of apolipoprotein B-containing lipoproteins from HeLa cells is dependent on expression of the microsomal triglyceride transfer protein and is regulated by lipid availability.

Defective functionality of HDL particles in familial apoA-I deficiency: relevance of alterations in HDL lipidome and proteome.

Transgenic mouse models of lipoprotein metabolism and atherosclerosis.

Distinct composition of human fetal HDL attenuates its anti-oxidative capacity

Human plasma phospholipid transfer protein specific activity is correlated with HDL size: implications for lipoprotein physiology.

A cholesteryl ester transfer complex in human plasma.

PXR agonism decreases plasma HDL levels in ApoE⁎3-Leiden.CETP mice

CETP does not affect triglyceride production or clearance in APOE*3-Leiden mice.

Analysis of lipid transfer activity between model nascent HDL particles and plasma lipoproteins: implications for current concepts of nascent HDL maturation and genesis.