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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Reymond, Cédric Lévesque, Dominique Bisaillon, Martin Perreault, Jean-Pierre |
| Description | Country affiliation: Canada Author Affiliation: Reymond C ( RNA Group/Groupe ARN, Département de Biochimie, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Québec J1H5N4, Canada.) |
| Abstract | Both the role and the interacting partners of an RNA molecule can change depending on its tertiary structure. Consequently, it is important to be able to accurately predict the complete folding pathway of an RNA molecule. The hepatitis delta virus (HDV) ribozyme is a small catalytic RNA with the greatest number of folding intermediates making it the model of choice with which to address this problem. The tertiary structures of the known putative intermediates along the folding pathway of the HDV ribozyme were predicted using the Macromolecular Conformations Symbolic programming (MC-Sym) software. The structures obtained by this method received physical support from Selective 2'-Hydroxyl Acylation analyzed by Primer Extension (SHAPE). The analysis of these structures elucidated several features of the HDV ribozyme. In addition, this report represents an application for MC-Sym that permits progression one step further toward the computer prediction of an RNA molecule-folding pathway. |
| File Format | HTM / HTML |
| ISSN | 09692126 |
| e-ISSN | 18784186 |
| DOI | 10.1016/j.str.2010.09.024 |
| Journal | Structure |
| Issue Number | 12 |
| Volume Number | 18 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-12-08 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Molecular Biology Discipline Biochemistry Discipline Biotechnology Hepatitis Delta Virus Genetics Molecular Conformation Nucleic Acid Conformation Rna, Catalytic Chemistry Catalysis Computational Biology Metabolism Models, Biological Models, Molecular Validation Studies As Topic Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Structural Biology Molecular Biology |
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