NDLI: Predicted critical environmental concentrations for 500 pharmaceuticals.

Please wait, while we are loading the content...

Assessment of undesirable events in cosmetic market surveillance: background, description and use of a causality assessment method in cosmetovigilance.

The value of acute toxicity studies to support the clinical management of overdose and poisoning: a cross-discipline consensus.

Acute oral toxicity: variability, reliability, relevance and interspecies comparison of rodent LD50 data from literature surveyed for the ACuteTox project.

An enhanced tiered toxicity testing framework with triggers for assessing hazards and risks of commodity chemicals.

The antipsychotics haloperidol and chlorpromazine increase bone metabolism and induce osteopenia in female rats.

Exposure-based waiving under REACH.

Acute and sub-chronic oral toxicological evaluations of quinocetone in Wistar rats.

Cytotoxicity of eight cigarette smoke condensates in three test systems: comparisons between assays and condensates.

Risk assessment of thujone in foods and medicines containing sage and wormwood--evidence for a need of regulatory changes?

Respiratory safety pharmacology: concurrent validation of volume, rate, time, flow and ratio variables in conscious male Sprague-Dawley rats.

Benchmark dose approaches in chemical health risk assessment in relation to number and distress of laboratory animals.

Review of fullerene toxicity and exposure--appraisal of a human health risk assessment, based on open literature.

Safety assessment of Cry1C protein from genetically modified rice according to the national standards of PR China for a new food resource.

Toxicogenomics and cancer risk assessment: a framework for key event analysis and dose-response assessment for nongenotoxic carcinogens.

Safety assessment of EPA-rich oil produced from yeast: Results of a 90-day subchronic toxicity study.

Integrating variability in half-lives and dietary intakes to predict mercury concentration in hair.

Limitations in the characterisation of cigarette products using different machine smoking regimes.

Predicted critical environmental concentrations for 500 pharmaceuticals.

A cross-sectional analysis of reported corporate environmental sustainability practices.

The evaluation of drug rechallenge: the casopitant Phase III program.

Year: 2010 Volume: 58 Issue: 3 Supplementary

Year: 2010 Volume: 58 Issue: 2

Year: 2010 Volume: 58 Issue: 1

Year: 2010 Volume: 57

Year: 2010 Volume: 56

Year: 2009 Volume: 55

Year: 2009 Volume: 54

Year: 2009 Volume: 53

Year: 2008 Volume: 52

Year: 2008 Volume: 51

Year: 2008 Volume: 50

Year: 2007 Volume: 48

Predicted critical environmental concentrations for 500 pharmaceuticals.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Fick, Jerker Lindberg, Richard H. Tysklind, Mats Larsson, D. G. Joakim
Spatial Coverage	Europe
Description	Country affiliation: Sweden Author Affiliation: Fick J ( Department of Chemistry, Umeå University, SE-901 87 Umeå, Sweden. jerker.fick@chem.umu.se)
Abstract	A growing number of pharmaceuticals are found in surface waters worldwide, raising concerns about their effects on aquatic organisms and it is a major challenge to develop a rational strategy for prioritizing drugs on which to focus the most extensive environmental research efforts. However, in contrast to most other chemicals, very good understanding of the human potency of pharmaceuticals has been obtained through efficacy and safety testing. Assuming that a drug acts primarily through the same target(s) also in a non-target species, it would be possible to predict the likelihood for pharmacological interactions in wildlife. Among aquatic organisms, fish most often share drug targets with humans. In this study, we have calculated the predicted critical environmental concentration (CECs), i.e. the surface water concentration expected to cause a pharmacological effect in fish, for 500 pharmaceuticals, assuming equivalent pharmacological activity. The CECs are based on literature data on human potencies together with a predicted bioconcentration factor in fish for each drug based on lipophilicity. We propose that CECs could be used as preliminary indicators of specific drugs' potential to cause adverse pharmacological effects at specific water concentrations, used when selecting pharmaceuticals to include in screening campaigns and for assessing relevant detection limits.
File Format	HTM / HTML
ISSN	02732300
Issue Number	3
Volume Number	58
e-ISSN	10960295
Journal	Regulatory Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2010-12-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Aquatic Organisms Drug Effects Drug Residues Toxicity Drug-related Side Effects And Adverse Reactions Environmental Exposure Environmental Monitoring Water Pollutants, Chemical Animals Analysis Europe Humans Pharmaceutical Preparations Risk Assessment Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine Toxicology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Human health risk assessment from the presence of human pharmaceuticals in the aquatic environment.

Introduction to the special issue on environmental risk assessment of pharmaceuticals.

Ecopharmacovigilance for better health.

Pharmaceuticals and personal care products: research needs for the next decade.

Reporting and evaluation criteria as means towards a transparent use of ecotoxicity data for environmental risk assessment of pharmaceuticals.

Prioritization of pharmaceuticals for potential environmental hazard through leveraging a large-scale mammalian pharmacological dataset.

Topical absorption and systemic toxicity.

Chronic toxicity of an environmentally relevant mixture of pharmaceuticals to three aquatic organisms (alga, daphnid, and fish).

Human pharmaceuticals in the marine environment: Focus on exposure and biological effects in animal species.

Predicted critical environmental concentrations for 500 pharmaceuticals.

Similar Documents

Human health risk assessment from the presence of human pharmaceuticals in the aquatic environment.

Introduction to the special issue on environmental risk assessment of pharmaceuticals.

Ecopharmacovigilance for better health.

Pharmaceuticals and personal care products: research needs for the next decade.

Reporting and evaluation criteria as means towards a transparent use of ecotoxicity data for environmental risk assessment of pharmaceuticals.

Prioritization of pharmaceuticals for potential environmental hazard through leveraging a large-scale mammalian pharmacological dataset.

Topical absorption and systemic toxicity.

Chronic toxicity of an environmentally relevant mixture of pharmaceuticals to three aquatic organisms (alga, daphnid, and fish).

Human pharmaceuticals in the marine environment: Focus on exposure and biological effects in animal species.

Predicted critical environmental concentrations for 500 pharmaceuticals.