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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lynch, Barry Simon, Ryan Roberts, Ashley |
| Description | Country affiliation: Canada Author Affiliation: Lynch B ( Cantox Health Sciences International, An Intertek Company, 2233 Argentia Road, Suite 308, Mississauga, ON, Canada. blynch@cantox.com) |
| Abstract | Aloesin is a chromone that is a component of Aloe spp. It may have potential as a functional food ingredient as it has been shown to likely have beneficial effects in persons in a pre-diabetic state or who have metabolic syndrome. In this study the safety of aloesin has been evaluated using a series of in vitro and in vivo genotoxicity assays including, bacterial mutation, mammalian cell cytogenetic, and mouse micronucleus tests. Aloesin did not induce reverse mutations in Salmonella typhimurium and Escherichia coli at any of the tested dose levels up to 10,000 µg/plate. Similarly, aloesin did not increase the incidence of chromosome aberrations when incubated with Chinese hamster lung cells at any of the tested concentrations up to 10,000 µg/mL. In vivo, there was no effect of aloesin on the incidence of micronucleated erythrocytes following oral administration on two consecutive days at doses up to 5000 mg/kg body weight. There was no evidence of toxicity to bone marrow. The results of these studies demonstrate that aloesin is without genotoxic potential. |
| File Format | HTM / HTML |
| ISSN | 02732300 |
| Issue Number | 2 |
| Volume Number | 61 |
| e-ISSN | 10960295 |
| Journal | Regulatory Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-11-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Chromones Toxicity Chromosome Aberrations Chemically Induced Glucosides Mutagens Animals Bone Marrow Drug Effects Cell Line Cricetinae Cricetulus Erythrocytes Escherichia Coli Female Male Mice Mice, Inbred Icr Micronucleus Tests Methods Mutagenicity Tests Rats Rats, Sprague-dawley Salmonella Typhimurium Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology |
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