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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hori, Hisako Takayanagi, Tomomi Kamada, Yoko Shimoyoshi, Satomi Ono, Yoshiko Kitagawa, Yoshinori Shibata, Hiroshi Nagao, Minako Fujii, Wataru Sakakibara, Yutaka |
| Description | Country affiliation: Japan Author Affiliation: Hori H ( Suntory Business Expert Limited, Shimamoto-cho, Mishima-gun, Osaka 618-8503, Japan. hisako_hori@suntory.co.jp) |
| Abstract | Sesamin is a major lignan that is present in sesame seeds and oil. Sesamin is partially converted to its stereoisomer, episesamin, during the refining process of non-roasted sesame seed oil. We evaluated the genotoxicity of these substances through the following tests: a bacterial reverse mutation assay (Ames test), a chromosomal aberration test in cultured Chinese hamster lung cells (CHL/IU), a bone marrow micronucleus (MN) test in Crlj:CD1 (ICR) mice, and a comet assay using the liver of Sprague-Dawley (SD) rats. Episesamin showed negative results in the Ames test with and without S9 mix, in the in vitro chromosomal aberration test with and without S9 mix, and in the in vivo comet assay. Sesamin showed negative results in the Ames test with and without S9 mix. In the in vitro chromosomal aberration test, sesamin did not induce chromosomal aberrations in the absence of S9 mix, but induced structural abnormalities at cytotoxic concentrations in the presence of S9 mix. Oral administration of sesamin at doses up to 2.0g/kg did not cause a significant increase in either the percentage of micronucleated polychromatic erythrocytes in the in vivo bone marrow MN test or in the % DNA in the comet tails in the in vivo comet assay of liver cells. These findings indicate that sesamin does not damage DNA in vivo and that sesamin and episesamin have no genotoxic activity. |
| File Format | HTM / HTML |
| ISSN | 13835718 |
| e-ISSN | 18793592 |
| Journal | Mutation Research/Genetic Toxicology and Environmental Mutagenesis |
| Issue Number | 1-2 |
| Volume Number | 719 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-02-03 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Cricetulus Toxicity Lignans Erythrocytes Salmonella Typhimurium Dna Damage Micronucleus Tests Dose-response Relationship, Drug Mutagenicity Tests Genetics Molecular Structure Liver Extracts Cricetinae Discipline Genetics Cells, Cultured Discipline Biochemistry Rats, Sprague-dawley Pharmacology Metabolism Drug Effects Comet Assay Dioxoles Mice, Inbred Icr Chemistry Animals Bone Marrow Cells Chromosome Aberrations Sesame Oil Mice Mutation Microsomes, Liver |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Health, Toxicology and Mutagenesis |
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