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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Van Acker, Frédérique Messinger, Horst Bär, Albert |
| Description | Country affiliation: Netherlands Author Affiliation: van Acker F ( TNO Triskelion BV, P.O. Box 844, 3700 AV Zeist, The Netherlands.); Messinger H ( Bioresco Ltd., Bundesstrasse 29, 4054 Basel, Switzerland.); Bär A ( Bioresco Ltd., Bundesstrasse 29, 4054 Basel, Switzerland. Electronic address: horst.messinger@bioresco.ch.) |
| Abstract | Vinyl laurate is a potential residual monomer in chewing gum base formulated with polyvinyl acetate vinyl laurate copolymer (PVAcVL). The genotoxic potential of vinyl laurate was examined in a battery of in vitro and in vivo genotoxicity tests. Vinyl laurate was not mutagenic in Ames tests. In addition, it was not mutagenic in the HPRT mutation assay in L5178Y cells. An in vitro mammalian chromosome aberration assay performed in CHO cells was equivocal. Vinyl laurate and/or its metabolites were not clastogenic in the mouse bone marrow micronucleus test. Kinetic data indicate that VL is metabolised to acetaldehyde and lauric acid. Both metabolites are well known and have been studied previously. Model calculations show, that any exposure to acetaldehyde from the consumption of PVAcVL containing chewing gum will remain far below levels of acetaldehyde exposure from food in which acetaldehyde occurs naturally. Direct exposure to VL will primarily be at the site of entry. The lack of toxicity in a 90-day repeated dose toxicity test, performed with VL doses up to approximately 3000 times higher than the maximal VL intake from the consumption of a typical piece of chewing gum, demonstrates a high safety margin. |
| File Format | HTM / HTML |
| ISSN | 02732300 |
| Issue Number | 1 |
| Volume Number | 72 |
| e-ISSN | 10960295 |
| Journal | Regulatory Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-06-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Laurates Toxicity Polymers Polyvinyls Animals Cho Cells Cell Line Chewing Gum Chromosome Aberrations Drug Effects Cricetulus Dna Damage Male Mice Micronucleus Tests Methods Mutagenicity Tests Mutagens Mutation Toxicity Tests Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology |
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