| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Yun, Jun-Won Che, Jeong-Hwan Kwon, Euna Kim, Yun-Soon Kim, Seung-Hyun You, Ji-Ran Kim, Woo Ho Kim, Hyeon Hoe Kang, Byeong-Cheol |
| Description |
Author Affiliation: Yun JW ( Department of Experimental Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.); Che JH ( Department of Experimental Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea); Kwon E ( Department of Experimental Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.); Kim YS ( Department of Experimental Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.); Kim SH ( Department of Experimental Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.); You JR ( Department of Experimental Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.); Kim WH ( Department of Pathology, Seoul National University College of Medicine, Seoul, Republic of Korea.); Kim HH ( Department of Urology, Seoul National University College of Medicine, Seoul, Republic of Korea.); Kang BC ( Department of Experimental Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea) |
| Abstract |
As a well-known traditional medicine, Angelica gigas (AG) and its active constituents, including decursin and decursinol, have been shown to possess several health beneficial properties such as anti-bacterial, immunostimulating, anti-tumor, neuroprotective, anti-nociceptive and anti-amnestic activities. However, there is lack of toxicity studies to assess potential toxicological concerns, especially long-term toxicity and genotoxicity, regarding the AG extract. Therefore, the safety of AG extract was assessed in subchronic toxicity and genotoxicity assays in accordance with the test guidelines published by the Organization for Economic Cooperation and Development. In a subchronic toxicity study for 13 weeks (125, 250, 500, 1000 and 2000 mg/kg body weight, delivered by gavage), data revealed no significant adverse effects of the AG extract in food consumption, body weight, mortality, hematology, biochemistry, necropsy, organ weight and histopathology throughout the study in male and female rats. These results suggest that no observed adverse effect level of the AG extract administered orally was determined to be greater than 2000 mg/kg/day, the highest dose tested. In addition, a battery of tests including Ames test, in vitro chromosome aberration assay and in vivo micronucleus assay suggested that the AG extract was not genotoxic. In conclusion, the AG extract appears to be safe as a traditional medicine for oral consumption. |
| File Format |
HTM / HTML |
| ISSN |
02732300 |
| Issue Number |
3 |
| Volume Number |
72 |
| e-ISSN |
10960295 |
| Journal |
Regulatory Toxicology and Pharmacology |
| Language |
English |
| Publisher |
Elsevier |
| Publisher Date |
2015-08-01 |
| Publisher Place |
Netherlands |
| Access Restriction |
One Nation One Subscription (ONOS) |
| Subject Keyword |
Discipline Pharmacology Angelica Plant Extracts Toxicity Animals Cell Line Cricetulus Female Male Mice, Inbred Icr Mutagenicity Tests No-observed-adverse-effect Level Plant Roots Rats, Inbred F344 Salmonella Typhimurium Drug Effects Genetics Toxicity Tests, Subacute Toxicity Tests, Subchronic Journal Article |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Medicine Toxicology |
