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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ng, K. P. Chanouzas, D. Fallouh, B. Baharani, J. |
| Description | Country affiliation: United kingdom Author Affiliation: Ng KP ( Renal Department, Birmingham Heartlands Hospital, Heart of England NHS Foundation Trust, Birmingham, UK. khaiping@doctors.org.uk) |
| Abstract | BACKGROUND: Severe acute kidney injury (AKI) occurs in 2-7% of all hospital admissions and is an independent poor prognostic marker. Nevertheless, information on the long-term outcome of AKI and the factors influencing this is limited. AIM: To describe the short- and long-term outcome of patients requiring renal replacement therapy (RRT) for severe AKI and to examine factors affecting patient survival and renal recovery. DESIGN AND METHODS: Single centre retrospective analysis of 481 consecutive patients over a period of 39 months. FOLLOW-UP: 12 months. PRIMARY AND SECONDARY OUTCOMES: overall mortality and RRT dependency at 30 days, 90 days and 1 year. RESULTS: Survival at 30 days, 90 days and 1 year was 54.4, 47.2 and 37.6%, respectively. RRT independency at 30 days, 90 days and 1 year was 35.2, 27.2 and 25.8%, respectively. Of those RRT independent at 90 days, 55% had ongoing chronic kidney disease. There were two distinct groups of patients: Group A (haemofiltration in ITU) and Group B (intermittent haemodialysis in the renal unit). Patient survival was worse in Group A while RRT independence was higher. Independent predictors of survival included renal cause of AKI and lower CI score in Group A and renal or post-renal cause of AKI, younger age and the absence of malignancy in Group B. Independent predictors of renal recovery included the presence of sepsis in Group A and pre- or post-renal cause of AKI in Group B. CONCLUSIONS: The short- and long-term survival outcome of severe AKI requiring RRT remains poor. Among those who survive, a significant number either continue to require RRT or have residual renal impairment necessitating ongoing follow-up. |
| File Format | HTM / HTML |
| ISSN | 14602725 |
| e-ISSN | 14602393 |
| Journal | QJM |
| Issue Number | 1 |
| Volume Number | 105 |
| Language | English |
| Publisher | Oxford University Press |
| Publisher Date | 2012-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Discipline Medicine Acute Kidney Injury Therapy Renal Replacement Therapy Etiology Mortality Early Diagnosis Glomerular Filtration Rate Retrospective Studies Risk Factors Sepsis Complications Sex Factors Survival Analysis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
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