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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | LaSalle, James R. |
| Description | Country affiliation: United States Author Affiliation: LaSalle JR ( Medical Arts Centers Inc., 950 North Jesse James Road, Excelsior Springs, MO 64024, USA. jlasalle4@aol.com) |
| Abstract | A large percentage of individuals with type 2 diabetes in the United States are not reaching their glycemic goals. In response to data from large outcomes trials and newer classes of therapeutic agents, various organizations and opinion-forming bodies recently updated their clinical practice recommendations for type 2 diabetes. The recommendations, as set by the American Diabetes Association (ADA)/European Association for the Study of Diabetes (EASD), the American Association of Clinical Endocrinologists/American College of Endocrinology, and the Canadian Diabetes Association, are similar in their emphasis on lifestyle modification and the importance of treating fasting and postprandial glucose, both of which are significant contributors to achieving glycated hemoglobin (HbA1c) targets. However, the recommendations differ in focus, depth, and specific treatment approaches. With the exception of the ADA/EASD consensus, dipeptidyl peptidase-4 (DPP-4) inhibitors have been included as alternative first- or second-line therapy due, in part, to their glucose-dependent mechanism of action that complements the actions of other oral antidiabetic drugs (OADs). The DPP-4 inhibitor, saxagliptin, demonstrates significant glycemia-lowering effects as monotherapy and in combination therapy, is weight neutral and well tolerated, and has a low risk of hypoglycemia. The added efficacy of saxagliptin in combination with other OADs in improving glycemic parameters has resulted in a significant proportion of patients achieving an HbA1c <7% versus monotherapy or active comparator. Combination therapy with saxagliptin can thus offer a potential advantage in achieving glycemic goals for the majority of patients with type 2 diabetes without additional tolerability concerns. |
| File Format | HTM / HTML |
| ISSN | 00325481 |
| Issue Number | 1 |
| Volume Number | 122 |
| e-ISSN | 19419260 |
| Journal | Postgraduate Medicine |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2010-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline medicine Adamantane Analogs & Derivatives Diabetes Mellitus, Type 2 Drug Therapy Dipeptides Therapeutic Use Dipeptidyl-peptidase Iv Inhibitors Hemoglobin A, Glycosylated Hyperglycemia Administration & Dosage Adverse Effects Algorithms Blood Glucose Drug Effects Blood Drug Therapy, Combination Analysis Humans Hypoglycemic Agents Metformin Sulfonylurea Compounds Journal Article Research Support, Non-u.s. Gov't Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
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