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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Varon, Joseph |
| Description | Country affiliation: United States Author Affiliation: Varon J ( The University of Texas Health Science Center at Houston, 2219 Dorrington St., Houston, TX 77030, USA. joseph.varon@uth.tmc.edu) |
| Abstract | The use of therapeutic hypothermia (TH) in acute care medicine has evolved over the past 2 centuries, and its use over the past decade has increased in emergency departments, intensive care units, and operating rooms. Therapeutic hypothermia has several potential clinical applications based on its putative mechanisms of action. It appears to improve oxygen supply to ischemic areas of the brain and decreases intracranial pressure. Mild-to-moderate TH (33 degrees C +/- 1 degrees C) after resuscitation from cardiac arrest is neuroprotective, and also acts on the cardiovascular system with evidence of a decrease in heart rate and increase in systemic vascular resistance. Therapeutic hypothermia decreases cardiac output by 7% for each 1 degrees C decrease in core body temperature, but maintains the stroke volume and the mean arterial pressure. Despite a growing amount of data, this life-saving technique is underutilized in hospitals worldwide. The purpose of this comprehensive review is to show the evolution and the clinical use of TH as it pertains to acute care practitioners. |
| File Format | HTM / HTML |
| ISSN | 00325481 |
| Issue Number | 1 |
| Volume Number | 122 |
| e-ISSN | 19419260 |
| Journal | Postgraduate Medicine |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2010-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline medicine Brain Injuries Therapy Heart Arrest Hyperthermia, Induced Hypoxia-ischemia, Brain Stroke Animals Cardiac Output History, 19th Century History, 20th Century History, 21st Century Humans Contraindications History Methods Liver Failure Spinal Cord Injuries Historical Article Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
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