| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Balakumar, Pitchai Varatharajan, Rajavel Nyo, Ying Hui Renushia, Raja Raaginey, Devarajan Oh, Ann Nah Akhtar, Shaikh Sohrab Rupeshkumar, Mani Sundram, Karupiah Dhanaraj, Sokkalingam A. |
| Description |
Author Affiliation: Balakumar P ( Pharmacology Unit, Faculty of Pharmacy, AIMST University, Semeling, 08100 Bedong, Malaysia. Electronic address: pbala2006@gmail.com.); Varatharajan R ( Pharmacology Unit, Faculty of Pharmacy, AIMST University, Semeling, 08100 Bedong, Malaysia.); Nyo YH ( Pharmacology Unit, Faculty of Pharmacy, AIMST University, Semeling, 08100 Bedong, Malaysia.); Renushia R ( Pharmacology Unit, Faculty of Pharmacy, AIMST University, Semeling, 08100 Bedong, Malaysia.); Raaginey D ( Pharmacology Unit, Faculty of Pharmacy, AIMST University, Semeling, 08100 Bedong, Malaysia.); Oh AN ( Pharmacology Unit, Faculty of Pharmacy, AIMST University, Semeling, 08100 Bedong, Malaysia.); Akhtar SS ( Pharmacology Unit, Faculty of Pharmacy, AIMST University, Semeling, 08100 Bedong, Malaysia.); Rupeshkumar M ( Pharmacology Unit, Faculty of Pharmacy, AIMST University, Semeling, 08100 Bedong, Malaysia.); Sundram K ( Pharmaceutical Chemistry Unit, Faculty of Pharmacy, AIMST University, Semeling, 08100 Bedong, Malaysia.); Dhanaraj SA ( Pharmaceutical Technology Unit, Faculty of Pharmacy, AIMST University, Semeling, 08100 Bedong, Malaysia.) |
| Abstract |
Low-doses of fenofibrate and dipyridamole have pleiotropic renoprotective actions in diabetic rats. This study investigated their combined effect relative to their individual treatments and lisinopril in rats with diabetic nephropathy. Streptozotocin (55mg/kg, i.p., once)-administered diabetic rats were allowed for 10 weeks to develop nephropathy. Diabetic rats after 10 weeks developed nephropathy with discernible renal structural and functional changes as assessed in terms of increase in kidney weight to body weight ratio (KW/BW), and elevations of serum creatinine, urea and uric acid, which accompanied with elevated serum triglycerides and decreased high-density lipoproteins. Hematoxylin-eosin, periodic acid Schiff and Masson trichrome staining confirmed renal pathological changes in diabetic rats that included glomerular capsular wall distortion, mesangial cell expansion, glomerular microvascular condensation, tubular damage and degeneration and fibrosis. Low-dose fenofibrate (30mg/kg, p.o., 4 weeks) and low-dose dipyridamole (20mg/kg, p.o., 4 weeks) treatment either alone or in combination considerably reduced renal structural and functional abnormalities in diabetic rats, but without affecting the elevated glucose level. Fenofibrate, but not dipyridamole, significantly prevented the lipid alteration and importantly the uric acid elevation in diabetic rats. Lisinopril (5mg/kg, p.o., 4 weeks, reference compound), prevented the hyperglycemia, lipid alteration and development of diabetic nephropathy. Lipid alteration and uric acid elevation, besides hyperglycemia, could play key roles in the development of nephropathy. Low-doses of fenofibrate and dipyridamole treatment either alone or in combination markedly prevented the diabetes-induced nephropathy. Their combination was as effective as to their individual treatment, but not superior in preventing the development of diabetic nephropathy. |
| File Format |
HTM / HTML |
| ISSN |
10436618 |
| Volume Number |
90 |
| e-ISSN |
10961186 |
| Journal |
Pharmacological Research |
| Language |
English |
| Publisher |
Elsevier |
| Publisher Date |
2014-12-01 |
| Publisher Place |
Netherlands |
| Access Restriction |
One Nation One Subscription (ONOS) |
| Subject Keyword |
Discipline Pharmacology Diabetes Mellitus, Experimental Drug Therapy Diabetic Nephropathies Prevention & Control Dipyridamole Therapeutic Use Fenofibrate Protective Agents Animals Blood Glucose Drug Effects Cholesterol Blood Creatinine Pathology Pharmacology Drug Therapy, Combination Kidney Lipoproteins, Hdl Lisinopril Male Organ Size Rats, Sprague-dawley Triglycerides Urea Uric Acid Journal Article Research Support, Non-u.s. Gov't |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Pharmacology |
