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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Dabak, Orçun Altun, Demet Arslan, Mutluay Yaman, Halil Vurucu, Sabahattin Yesilkaya, Ediz Unay, Bulent |
| Description | Country affiliation: Turkey Author Affiliation: Dabak O ( Department of Pediatrics, Etimesgut Military Hospital, Ankara, Turkey.); Altun D ( Department of Pediatrics, Ufuk University School of Medicine, Ankara, Turkey. Electronic address: demet.altun@ufuk.edu.tr.); Arslan M ( Department of Pediatrics, Gülhane Military Medical Academy and Medical Faculty, Ankara, Turkey.); Yaman H ( Department of Biochemistry, Gülhane Military Medical Academy and Medical Faculty, Ankara, Turkey.); Vurucu S ( Department of Pediatric Neurology, Gülhane Military Medical Academy and Medical Faculty, Ankara, Turkey.); Yesilkaya E ( Department of Pediatric Endocrinology, Gülhane Military Medical Academy and Medical Faculty, Ankara, Turkey.); Unay B ( Department of Pediatric Neurology, Gülhane Military Medical Academy and Medical Faculty, Ankara, Turkey.) |
| Abstract | BACKGROUND: Melatonin modulates central nervous system neuronal activity. We compared the melatonin levels of patients with febrile and afebrile seizures during and after seizure with those of healthy controls. METHODS: We enrolled 59 individuals with afebrile and febrile seizures (mean age, 6.09 ± 4.46 years) and 28 age-, sex-, and weight-matched healthy children. Melatonin levels were measured near the time of a seizure (0 to 1 hour) and at 12 and 24 hours post-seizure, and control melatonin levels were measured from a single venous blood sample. RESULTS: Plasma melatonin levels increased during seizures in the study group (P < 0.001). Post-seizure plasma melatonin levels were significantly lower in the study group than in the control group (P < 0.05). Plasma melatonin levels did not differ between patients with afebrile seizures who had and had not used antiepileptic drugs. Daytime (8 AM to 8 PM) and nighttime (8 PM to 8 AM) post-seizure melatonin levels were not significantly different. CONCLUSIONS: Melatonin levels were lower in pediatric patients prone to seizures than in healthy children and increased during seizures. Further research is needed to test the role of melatonin in the pathophysiology and treatment of epilepsy. |
| File Format | HTM / HTML |
| ISSN | 08878994 |
| Journal | Pediatric Neurology |
| Volume Number | 57 |
| e-ISSN | 18735150 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-04-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Neurology Discipline Pediatrics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology Neurology (clinical) Pediatrics, Perinatology and Child Health Developmental Neuroscience |
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