| Author |
Higuchi, Yousuke Kubo, Toshihide Mitsuhashi, Toshiharu Nakamura, Naoko Yokota, Ichiro Komiyama, Osamu Kamimaki, Isamu Yamamoto, Shigenori Uchida, Yasushi Watanabe, Kyoko Yamashita, Hironori Tanaka, Shigeki Iguchi, Kosei Ichimi, Ryouji Miyagawa, Shinichiro Takayanagi, Toshimitsu Koga, Hiroshi Shukuya, Akinori Saito, Akiko Horibe, Keizo |
| Description |
Country affiliation: Japan Author Affiliation: Higuchi Y ( Department of Pediatrics, National Hospital Organization Okayama Medical Center, Okayama, Okayama, Japan); Kubo T ( Department of Pediatrics, National Hospital Organization Okayama Medical Center, Okayama, Okayama, Japan. Electronic address: kubocchi@okayamamc.jp.); Mitsuhashi T ( Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama, Japan.); Nakamura N ( Department of Pediatrics, National Hospital Organization Shikoku Medical Center for Children and Adults, Zentsuji, Kagawa, Japan.); Yokota I ( Department of Pediatrics, National Hospital Organization Shikoku Medical Center for Children and Adults, Zentsuji, Kagawa, Japan.); Komiyama O ( Department of Pediatrics, National Hospital Organization Tokyo Medical Center, Meguro-ku, Tokyo, Japan.); Kamimaki I ( Department of Pediatrics, Saitama National Hospital, Wako, Saitama, Japan.); Yamamoto S ( Department of Pediatrics, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba, Japan.); Uchida Y ( Department of Pediatrics, National Hospital Organization Nagara Medical Center, Gifu, Gifu, Japan.); Watanabe K ( Department of Pediatrics, National Hospital Organization Kokura Medical Center, Kitakyushu, Fukuoka, Japan.); Yamashita H ( Department of Pediatrics, National Hospital Organization Kokura Medical Center, Kitakyushu, Fukuoka, Japan.); Tanaka S ( Department of Pediatrics, National Hospital Organization Miechuo Medical Center, Tsu, Mie, Japan.); Iguchi K ( Department of Pediatrics, Mie National Hospital, Tsu, Mie, Japan.); Ichimi R ( Department of Pediatrics, Mie National Hospital, Tsu, Mie, Japan.); Miyagawa S ( Department of Pediatrics, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Hiroshima, Japan.); Takayanagi T ( Department of Pediatrics, National Hospital Organization Saga National Hospital, Saga, Saga, Japan.); Koga H ( Department of Pediatrics, National Hospital Organization Beppu Medical Center, Beppu, Oita, Japan.); Shukuya A ( Department of Pediatrics, National Hospital Organization Sagamihara National Hospital, Sagamihara, Kanagawa, Japan.); Saito A ( Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya Clinical Research Center, Nagoya, Aichi, Japan.); Horibe K ( Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya Clinical Research Center, Nagoya, Aichi, Japan.) |
| Abstract |
BACKGROUND: We investigated features and responses to treatment in patients with febrile and afebrile convulsions with mild gastroenteritis and characterized convulsions with rotavirus and norovirus gastroenteritis. METHODS: We conducted a prospective, observational study to evaluate patients with febrile and afebrile convulsions with mild gastroenteritis who were hospitalized between November 2011 and March 2014 at 13 facilities in the National Hospital Organization. We classified the patients into two groups: presence or absence of fever. We investigated the background, clinical and laboratory characteristics, viral antigen in stool, and efficacy of anticonvulsant drugs. RESULTS: Of 126 patients enrolled in this study, 50 were febrile (Fc group) and 76 were afebrile (aFc group). A family history of febrile seizures was significantly more frequent in the Fc group than in the aFc group (28.0% vs 9.2%, P = 0.005). Clinical characteristics were similar between the rotavirus and norovirus groups, but fever was significantly more frequent in the rotavirus group (46.2% vs 8.3%, P < 0.001). Serum sodium levels were significantly negatively related to the number of seizures in the aFc group (ß = -0.13; 95% confidence interval, -0.24, -0.03; P = 0.01). Carbamazepine was significantly more efficacious than diazepam suppositories in the aFc group (odds ratio = 49.3, 95% confidence interval, 2.35, 1037; P = 0.01). CONCLUSION: Febrile convulsions with mild gastroenteritis show characteristics of both febrile seizures and convulsions with mild gastroenteritis. Carbamazepine is optimal for convulsions with mild gastroenteritis. Clinical features of convulsions with rotavirus and norovirus gastroenteritis are similar, except for fever. Serum sodium levels may play a major role in the onset of convulsions with mild gastroenteritis. |
