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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Balamurugan, Mariappan Parthasarathi, Kasi Ranganathan, Lalpet Souri Cooper, Edwin L. |
| Description | Country affiliation: India Author Affiliation: Balamurugan M ( Division of Vermibiotechnology, Department of Zoology, Annamalai University, Annamalai Nagar-608002, India. dnabala@rediffmail.com) |
| Abstract | The hepatoprotective potential of earthworm extract (EE) (Lampito mauritii, Kinberg) was evaluated against paracetamol-induced liver injury in Wistar albino rat, in comparison with silymarin, the standard hepatoprotective drug. We observed a reduction in liver antioxidants, such as glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) and in serum total protein, and an increase in serum alkaline phosphatase (ALP), serum aspertate aminotranferase (AST), serum alanine aminotranferase (ALT), bilirubin and liver thiobarbituric acid reactive substances (TBARS) due to liver injury in the paracetamol-administered rats (2 g/kg). On the contrary, increased activities of liver GSH, SOD, GPx, CAT and serum total protein level, and decrease in the contents of serum ALP, AST, ALT, bilirubin and liver TBARS were observed in rats administered with different doses of EE (100, 200 and 300 mg/kg), which are similar to the activities of hepatoprotective drug silymarin (150 mg/kg). The mode of action of EE as evidenced by the above parameters may suggest that EE, on the one hand, prevents the formation of the reactive oxygen groups, or scavenges these groups, thereby preventing the damage on the hepatic cells, and, on the other hand, modulates the genes responsible for synthesis of antioxidant enzymes such as GPx, CAT and SOD in liver tissue and decreases the serum enzymatic activities such as ALP, AST and ALT. |
| File Format | HTM / HTML |
| ISSN | 16731581 |
| e-ISSN | 18621783 |
| DOI | 10.1631/jzus.B0720194 |
| Journal | Journal of Zhejiang University SCIENCE B |
| Issue Number | 2 |
| Volume Number | 9 |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2008-02-01 |
| Publisher Place | China |
| Access Restriction | Open |
| Subject Keyword | Discipline Biomedicine Discipline Biotechnology Antioxidants Metabolism Glutathione Liver Acetaminophen Pharmacology Animals Glutathione Peroxidase Lipid Peroxidation Drug Effects Pathology Models, Biological Models, Statistical Oligochaeta Oxidative Stress Rats, Wistar Thiobarbituric Acid Reactive Substances |
| Content Type | Text |
| Resource Type | Article |
| Subject | Veterinary Medicine Biochemistry, Genetics and Molecular Biology Pharmacology, Toxicology and Pharmaceutics |
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