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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Konopska, Boguslawa Gburek, Jakub Golab, Krzysztof Warwas, Maria |
| Description | Country affiliation: Poland Author Affiliation: Konopska B ( Department of Pharmaceutical Biochemistry, Wroclaw Medical University, Wroclaw, Poland. boguslawa.konopska@umed.wroc.pl) |
| Abstract | OBJECTIVES: Drug-induced kidney injury is a serious adverse event which needs to be monitored during aminoglycoside therapy. Urine cystatin C is considered an early and sensitive marker of nephrotoxicity. Cystatin C, a low-molecular-weight serum protein, and basic drugs have a common transport system expressed in the apical membrane of renal proximal tubular cells. The aim of this study was to investigate whether aminoglycoside antibiotics influenced cystatin C binding to the renal brush-border membrane. METHODS: The binding study was performed using a rapid filtration technique and affinity column displacement method. KEY FINDINGS: Concentration-dependent inhibition of chicken cystatin binding to brush-border membranes by gentamicin was observed. The gentamicin interaction with brush-border membranes was of relatively low affinity (Ki = 32 µm) in comparison with the chicken cystatin affinity to the binding sites (Kd = 3.6 µm). Amikacin and gentamicin were only able to displace chicken cystatin from the chromatographic affinity column in concentrations several times higher than normally found in the tubular fluid during standard aminoglycoside therapy. CONCLUSION: Cystatin reabsorption in the proximal tubule cannot be significantly affected by aminoglycoside antibiotics because of their relatively low affinity to common binding sites on the brush-border membrane. |
| File Format | HTM / HTML |
| ISSN | 00223573 |
| Issue Number | 7 |
| Volume Number | 65 |
| e-ISSN | 20427158 |
| Journal | Journal of Pharmacy and Pharmacology |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2013-07-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Amikacin Pharmacology Cystatin C Metabolism Gentamicins Microvilli Administration & Dosage Toxicity Aminoglycosides Animals Anti-bacterial Agents Binding Sites Chickens Chromatography, Affinity Dose-response Relationship, Drug Kidney Tubules, Proximal Drug Effects Male Rats Rats, Inbred Buf Comparative Study Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Pharmaceutical Science |
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