NDLI: Anxiolytic-like effects of 4-O-methylhonokiol isolated from Magnolia officinalis through enhancement of GABAergic transmission and chloride influx.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Han, Huishan Jung, Jae Kyung Han, Sang Bae Nam, Sang Yoon Oh, Ki Wan Hong, Jin Tae
Description	Author Affiliation: Han H ( College of Pharmacy, Chungbuk National University, Cheongju, Korea.)
Abstract	Abstract This study investigated the anxiolytic-like effects of 4-O-methylhonokiol, a neolignan compound of Magnolia officinalis, by using the experimental paradigms of anxiety and compared the results with those of a known anxiolytic, diazepam. A single treatment with 4-O-methylhonokiol (0.1, 0.2, and 0.5 mg/kg, p.o.) or treatment for 7 days (0.5 mg/kg in drinking water) increased the percentage of time spent in the open arms and the number of open arms entries in the elevated plus-maze test. However, the 4-O-methylhonokiol-increased percentage of time spent in the open arm was abolished by treatment with flumazenil, a benzodiazepine receptor antagonist (10 mg/kg). 4-O-Methylhonokiol also increased the number of head dips in the hole-board test, but decreased locomotor activity. Molecular experiments revealed that the 1-subunit of Î³-aminobutyric acid (GABA) type A receptors was overexpressed in the cortex of brains of mice after treatment with 4-O-methylhonokiol for 7 days. In addition, 4-O-methylhonokiol also increased chloride influx in cultured cortical cells. It is concluded that 4-O-methylhonokiol may have anxiolytic-like effects and that these effects may be mediated by GABAergic transmission with the increase of Cl(-) channel opening.
File Format	HTM / HTML
ISSN	1096620X
Issue Number	7-8
Volume Number	14
e-ISSN	15577600
Journal	Journal of Medicinal Food
Language	English
Publisher	Mary Ann Liebert, Inc.
Publisher Date	2011-07-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Discipline Nutritional Sciences Anti-anxiety Agents Administration & Dosage Anxiety Drug Therapy Biphenyl Compounds Chlorides Metabolism Lignans Magnolia Chemistry Plant Extracts Gamma-aminobutyric Acid Animals Genetics Physiopathology Biological Transport Drug Effects Ethics Brain Disease Models, Animal Humans Male Maze Learning Mice Mice, Inbred Icr Motor Activity Rats Rats, Sprague-dawley Receptors, Gaba-a Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Medicine

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