NDLI: Dose of intraoperative remifentanil administration is independently associated with increase in the risk of postoperative nausea and vomiting in elective mastectomy under general anesthesia.

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Dose of intraoperative remifentanil administration is independently associated with increase in the risk of postoperative nausea and vomiting in elective mastectomy under general anesthesia.

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Dose of intraoperative remifentanil administration is independently associated with increase in the risk of postoperative nausea and vomiting in elective mastectomy under general anesthesia.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hozumi, Jun Egi, Moritoki Sugita, Shinji Sato, Tetsufumi
Description	Country affiliation: Japan Author Affiliation: Hozumi J ( Department of Anesthesia and Intensive Care, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.); Egi M ( Department of Anesthesiology, Kobe University Hospital, 7-5-2, Kusunoki cho, Chuo-ku, Kobe City, Hyogo 650-0017, Japan. Electronic address: moriori@tg8.so-net.ne.jp.); Sugita S ( Department of Anesthesiology and Pain Medicine, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, 113-8602, Japan.); Sato T ( Department of Anesthesiology and Pain Medicine, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, 113-8602, Japan.)
Abstract	BACKGROUND: Postoperative nausea and vomiting (PONV) is one of the common complications in patients who have undergone surgery with general anesthesia. The association of intraoperative use of remifentanil with PONV has remained controversial. The aim of the current study was to determine the association of dose of intraoperative remifentanil administration with incidence of PONV. METHODS: The present study was a single-center retrospective observational study and included 423 female patients with American Society of Anesthesiologists physical status I or II who underwent elective mastectomy under general anesthesia between October 2011 and October 2012. The incidence of PONV within 3 days after the operation was prospectively assessed. The time-weighted average of remifentanil during the operation (twRem) was calculated. We used a multivariate regression model to assess the independent association of the twRem with the incidence of PONV. RESULTS: Among 423 patients, 129 patients (30.5%) had PONV during the study period. Remifentanil was administrated in 355 patients (83.9%). In the multivariate logistic regression model using categories of twRem, we found that increased twRem was independently associated with increase in the risk of PONV (P=.01). There was an independent association between twRem greater than 0.2 µg/kg per minute and increase in the risk of PONV. CONCLUSION: This retrospective observational study revealed a dose-dependent association between dose of intraoperative remifentanil administration and increase in the risk of PONV. Time-weighted average of remifentanil greater than 0.2 µg/kg per minute was independently associated with risk of PONV.
File Format	HTM / HTML
ISSN	09528180
Journal	Journal of Clinical Anesthesia
Volume Number	34
e-ISSN	18734529
Language	English
Publisher	Elsevier
Publisher Date	2016-11-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Anesthesiology
Content Type	Text
Resource Type	Article
Subject	Anesthesiology and Pain Medicine

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