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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sternberg, Katrin Gratz, Matthias Koeck, Kathleen Mostertz, Joerg Begunk, Robert Loebler, Marian Semmling, Beatrice Seidlitz, Anne Hildebrandt, Petra Homuth, Georg Grabow, Niels Tuemmler, Conny Weitschies, Werner Schmitz, Klaus-Peter Kroemer, Heyo K. |
| Description | Country affiliation: Germany Author Affiliation: Sternberg K ( University of Rostock, Medical Faculty, Institute for Biomedical Engineering, Rostock, Germany. katrin.sternberg@uni-rostock.de) |
| Abstract | Magnesium-based bioabsorbable cardiovascular stents have been developed to overcome limitations of permanent metallic stents, such as late stent thrombosis. During stent degradation, endothelial and smooth muscle cells will be exposed to locally high magnesium concentrations with yet unknown physiological consequences. Here, we investigated the effects of elevated magnesium concentrations on human coronary artery endothelial and smooth muscle cell (HCAEC, HCASMC) growth and gene expression. In the course of 24 h after incubation with magnesium chloride solutions (1 or 10 mM) intracellular magnesium level in HCASMC raised from 0.55 ± 0.25 mM (1 mM) to 1.38 ± 0.95 mM (10 mM), while no increase was detected in HCAEC. Accordingly, a DNA microarray-based study identified 69 magnesium regulated transcripts in HCAEC, but 2172 magnesium regulated transcripts in HCASMC. Notably, a significant regulation of various growth factors and extracellular matrix components was observed. In contrast, viability and proliferation of HCAEC were increased at concentrations of up to 25 mM magnesium chloride, while in HCASMC viability and proliferation appeared to be unaffected. Taken together, our data indicate that magnesium halts smooth muscle cell proliferation and stimulates endothelial cell proliferation, which might translate into a beneficial effect in the setting of stent associated vascular injury. |
| File Format | HTM / HTML |
| ISSN | 15524973 |
| Issue Number | 1 |
| Volume Number | 100 |
| e-ISSN | 15524981 |
| Journal | Journal of Biomedical Materials Research Part B: Applied Biomaterials |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2012-01-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biomedical engineering Absorbable Implants Cell Proliferation Coronary Vessels Metabolism Endothelial Cells Magnesium Muscle, Smooth, Vascular Myocytes, Smooth Muscle Stents Cell Survival Cells, Cultured Cytology Injuries Gene Expression Regulation Humans Materials Testing Methods Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biomaterials Biomedical Engineering |
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