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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Huang, Di Zuo, Yi Zou, Qin Wang, Yanying Gao, Shibo Wang, Xiaoyan Liu, Haohuai Li, Yubao |
| Description | Author Affiliation: Huang D ( Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu, People's Republic of China.) |
| Abstract | High porosity of scaffold is always accompanied by poor mechanical property; the aim of this study was to enhance the strength and modulus of the highly porous scaffold of nanohydroxyapatite/polyamide66 (n-HA/PA66) by coating chitosan (CS) and to investigate the effect of CS content on the scaffold physical properties and cytological properties. The results show that CS coating can reinforce the scaffold effectively. The compress modulus and strength of the CS coated n-HA/PA66 scaffolds are improved to 32.71 and 2.38 MPa, respectively, being about six times and five times of those of the uncoated scaffolds. Meanwhile, the scaffolds still exhibit a highly interconnected porous structure and the porosity is approximate about 78%, slightly lower than the value (84%) of uncoated scaffold. The cytological properties of scaffolds were also studied in vitro by cocultured with osteoblast-like MG63 cells. The cytological experiments demonstrate that the reinforced scaffolds display favorable cytocompatibility and have no significant difference with the uncoated n-HA/PA66 scaffolds. The CS reinforced n-HA/PA66 scaffolds can meet the basic mechanical requirement of bone tissue engineering scaffold, presenting a potential for biomedical application in bone reconstruction and repair. |
| File Format | HTM / HTML |
| ISSN | 15524973 |
| Issue Number | 1 |
| Volume Number | 100 |
| e-ISSN | 15524981 |
| Journal | Journal of Biomedical Materials Research Part B: Applied Biomaterials |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2012-01-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biomedical engineering Bone And Bones Chitosan Chemistry Coated Materials, Biocompatible Durapatite Nanocomposites Nylons Tissue Engineering Methods Tissue Scaffolds Bone Regeneration Cell Line, Tumor Humans Materials Testing Porosity Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biomaterials Biomedical Engineering |
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