NDLI: Topographical extracellular matrix cues on anticancer drug-induced cytotoxicity in stem cells.

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Topographical extracellular matrix cues on anticancer drug-induced cytotoxicity in stem cells.

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Topographical extracellular matrix cues on anticancer drug-induced cytotoxicity in stem cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kim, Jangho Kim, Yeon Ju Bae, Won-Gyu Jang, Kyung-Jin Lim, Ki Taek Choung, Pill-Hoon Choung, Yun-Hoon Chung, Jong Hoon
Description	Author Affiliation: Kim J ( Department of Biosystems & Biomaterials Science and Engineering, Seoul National University, Seoul, 151-742, Republic of Korea.); Kim YJ ( Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, 151-742, Republic of Korea.); Bae WG ( Department of Otolaryngology, Ajou University School of Medicine, Suwon, 443-721, Republic of Korea.); Jang KJ ( School of Mechanical and Aerospace Engineering, Seoul National University, Seoul, 301-1202, Republic of Korea.); Lim KT ( Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts, 02115.); Choung PH ( Department of Biosystems & Biomaterials Science and Engineering, Seoul National University, Seoul, 151-742, Republic of Korea.); Choung YH ( Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University, Seoul, 110-749, Republic of Korea.); Chung JH ( Department of Otolaryngology, Ajou University School of Medicine, Suwon, 443-721, Republic of Korea.)
Abstract	In recent years, cell chip-based platforms have begun to show promise as a means of corroborating the findings of in vivo animal tests for cytotoxicity, and perhaps in the future partially replacing the need for such animal models. In contrast to the conventional culture methods, micro- and nanofabrication techniques can be utilized to provide a set of mechanostimulatory signals to the cells that mimic the context of extracellular matrix (ECM) of the tissue in which a particular cell line resides. Here, we report periodic lateral topographic striations, with a pitch ranging approximately from 200 to 800 nm with an intention to mimic a common geometry of fibrils in the ECM such as collagen or elastin, as a platform for investigating anticancer drug-induced cytotoxicity in stem cells. The ECM cues could facilitate perimeter, elongation, and gap junction formation of mesenchymal stem cells (MSCs), which eventually influenced the fate of cells in terms of death and survival against the common chemotherapeutic agent cisplatin. Interestingly, the appropriate inhibition of gap junctions of MSCs on the ECM mimicking substrates could prevent the cisplatin-induced cytotoxicity through the inhibition of the cisplatin-induced 'death signal communication' as compared to that on the flat substrates. Our results imply that nanoscale topography is an important consideration for chip-based cytotoxicity assays, which uniquely enable the consideration and rational design of ECM-like topographic features, and furthermore, that the natural topography of the ECM in the context of stem cell niches may serve as an important indicator for chemotherapeutic agent sensitivity.
File Format	HTM / HTML
ISSN	15524973
Issue Number	6
Volume Number	103
e-ISSN	15524981
Journal	Journal of Biomedical Materials Research Part B: Applied Biomaterials
Language	English
Publisher	Wiley
Publisher Date	2015-08-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Biomedical engineering Antineoplastic Agents Pharmacology Biomimetic Materials Chemistry Extracellular Matrix Mesenchymal Stromal Cells Metabolism Cell Survival Drug Effects Gap Junctions Hela Cells Humans Cytology Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biomedical Engineering

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