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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Tambe, Nisarg Di, Jin Zhang, Ze Bernacki, Susan El-Shafei, Ahmed King, Martin W. |
| Description | Author Affiliation: Tambe N ( College of Textiles, North Carolina State University, Raleigh, North Carolina.); Di J ( College of Textiles, North Carolina State University, Raleigh, North Carolina.); Zhang Z ( Department of Biomedical Engineering, North Carolina State University, Raleigh, North Carolina.); Bernacki S ( Department of Surgery, Faculty of Medicine, Laval University, Quebec, Quebec, Canada.); El-Shafei A ( Department of Biomedical Engineering, North Carolina State University, Raleigh, North Carolina.); King MW ( College of Textiles, North Carolina State University, Raleigh, North Carolina.) |
| Abstract | The material surface plays an important role in the case of biomaterials used as tissue engineering scaffolds. On exposure to a biological environment, extra cellular matrix (ECM) proteins are adsorbed non-specifically onto the surface and cells interact indirectly with the surface through the adsorbed proteins. Most synthetic polymeric biomaterials lack the desirable surface properties for cells as well as have poor cellular adhesion due to their hydrophobic nature. The main objective of this study was to harness surface functionalization technologies to fabricate scaffolds that would be biocompatible and support the adhesion and proliferation of fibroblast cells. The collagen was immobilized on the surface of functionalized PLA via a novel natural cross-linking molecule genipin which resulted in improved cell proliferation of human dermal fibroblasts as compared to the PLA surface coated with collagen without genipin. It is believed that genipin helps reduce steric problems between the functional groups and large protein molecules, and enables immobilized peptide to move more freely in a biological environment. |
| File Format | HTM / HTML |
| ISSN | 15524973 |
| Issue Number | 6 |
| Volume Number | 103 |
| e-ISSN | 15524981 |
| Journal | Journal of Biomedical Materials Research Part B: Applied Biomaterials |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2015-08-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biomedical engineering Fibroblasts Metabolism Iridoids Chemistry Lactic Acid Materials Testing Polymers Tissue Engineering Tissue Scaffolds Cells, Cultured Cytology Humans Polyesters Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biomaterials Biomedical Engineering |
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