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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Meteran, Howraman Meteran, Hanieh Porsbjerg, Celeste Backer, Vibeke |
| Description | Country affiliation: Denmark Author Affiliation: Meteran H ( a Respiratory Research Unit , Bispebjerg University Hospital , Copenhagen , Denmark.); Meteran H ( a Respiratory Research Unit , Bispebjerg University Hospital , Copenhagen , Denmark.); Porsbjerg C ( a Respiratory Research Unit , Bispebjerg University Hospital , Copenhagen , Denmark.); Backer V ( a Respiratory Research Unit , Bispebjerg University Hospital , Copenhagen , Denmark.) |
| Abstract | AIM: To provide a general overview of the current biological treatments and discuss their potential anti-asthmatic effects. DATA SOURCES: We reviewed articles in PubMed found using the search words 'Asthma/therapy AND antibodies, monoclonal/therapeutic use AND cytokines.' STUDY SELECTIONS: Only articles published in English since 2000 were considered. The search identified 29 studies; 8 additional studies were found by hand search, generating 37 studies. RESULTS: Of the 37 studies investigating biological treatments of asthma, 5 were on the effects of anti-IgE (omalizumab); 12 on anti-IL-5; 8 on anti-IL-13; 5 on anti-IL-4R- ; 3 on anti-IL-9; one on TNF- ; one on anti-IL-2R- ; one on TSLP (Thymic Stromal Lymphopoietin); and one on OX40L. Sample sizes ranged from 3 to 943 participants. Studies of therapies targeting IgE, IL-2, IL4R- , IL-5, and IL-13 showed some efficacy, whereas those targeting TSLP, IL-9, and TNF- lacked convincing effectiveness. CONCLUSION: Research on the biological treatment of asthma shows promising results. While anti-IgE (omalizumab) has been used in the treatment of asthma for some years, anti-IL-5 has recently been approved for use. The efficacy of results of other large studies with a longer duration is needed to draw a firm conclusion. Such studies should not only focus on clinical outcomes, but also consider asthma-related quality of life. Knowledge on the asthma phenotypes and identification of biomarkers associated with these will be useful for physicians considering the right treatment for the asthma patient. |
| File Format | HTM / HTML |
| ISSN | 02770903 |
| Journal | Journal of Asthma |
| e-ISSN | 15324303 |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2017-03-13 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pulmonology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pulmonary and Respiratory Medicine Immunology and Allergy Pediatrics, Perinatology and Child Health |
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