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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lacaze, L. Scotté, M. |
| Description | Country affiliation: France Author Affiliation: Lacaze L ( Digestive Surgery Department, Rouen University Hospital, Rouen, France.) |
| Abstract | INTRODUCTION: Bevacizumab, a humanized monoclonal antibody against vascular endothelial growth factor has demonstrated a significant benefit on overall survival (OS) and progression free survival (PFS) in patients with metastatic colorectal carcinoma. Many adverse effects of Bevacizumab are well-known. We report here the first case of diaphragmatic perforation after Bevacizumab treatment. PATIENTS AND METHODS: A case of Bevacizumab induced diaphragmatic perforation was reported and a search of PubMed and Cochrane databases was performed in order to review relevant literature on the adverse effects of Bevacizumab. DISCUSSION: Serious late surgical complications may occur even if the delay between surgery and Bevacizumab treatment is respected. These complications may be life threatening for patients, and demonstrate the importance of careful monitoring after postoperative administration of Bevacizumab. |
| File Format | HTM / HTML |
| ISSN | 07487983 |
| Issue Number | 11 |
| Volume Number | 38 |
| e-ISSN | 15322157 |
| Journal | European Journal of Surgical Oncology (EJSO) |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-11-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline General Surgery Discipline Oncology Angiogenesis Inhibitors Adverse Effects Antibodies, Monoclonal, Humanized Diaphragm Muscular Diseases Chemically Induced Therapeutic Use Bevacizumab Colonic Neoplasms Pathology Female Humans Liver Neoplasms Drug Therapy Secondary Lung Neoplasms Middle Aged Rupture, Spontaneous Case Reports Journal Article |
| Content Type | Text |
| Resource Type | Case study Article |
| Subject | Surgery Oncology |
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