NDLI: Expression and prognostic significance of thymidylate synthase (TS) in pancreatic head and periampullary cancer.

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Expression and prognostic significance of thymidylate synthase (TS) in pancreatic head and periampullary cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Van Der Zee, J. A. Van Eijck, C. H. J. Hop, W. C. J. Van Dekken, H. Dicheva, B. M. Seynhaeve, A. L. B. Koning, G. A. Eggermont, A. M. M. Ten Hagen, T. L. M.
Description	Country affiliation: Netherlands Author Affiliation: van der Zee JA ( Laboratory of Experimental Surgical Oncology, Section Surgical Oncology, Department of Surgery, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands. j.a.vanderzee@erasmusmc.nl)
Abstract	BACKGROUND: Pancreatic cancer has a dismal prognosis. Attempts have been made to improve outcome by several 5-FU based adjuvant treatment regimens. However, the results are conflicting. There seems to be a continental divide with respect to the use of 5-FU based chemoradiotherapy (CRT). Furthermore, evidence has been presented showing a different response of pancreatic head and periampullary cancer to 5-FU based CRT. Expression of thymidylate synthase (TS) has been associated with improved outcome following 5-FU based adjuvant treatment in gastrointestinal cancer. This prompted us to determine the differential expression and prognostic value of TS in pancreatic head and periampullary cancer. PATIENTS AND METHODS: TS protein expression was studied by immunohistochemistry on original paraffin embedded tissue from 212 patients following microscopic radical resection (R0) of pancreatic head (n = 98) or periampullary cancer (n = 114). Expression was investigated for associations with recurrence free (RFS), cancer specific (CSS) and overall survival (OS), and conventional prognostic factors. RESULTS: High cytosolic TS expression was present in 26% of pancreatic head tumours and 37% of periampullary tumours (p = .11). Furthermore, TS was an independent factor predicting favourable outcome following curative resection of pancreatic head cancer (p = .003, .001 and .001 for RFS, CSS and OS, respectively). In contrast, in periampullary cancer, TS was not associated with outcome (all p > .10). CONCLUSION: TS, was found to be poorly expressed in both pancreatic head and periampullary cancer and identified as an independent prognostic factor following curative resection of pancreatic head cancer.
File Format	HTM / HTML
ISSN	07487983
Issue Number	11
Volume Number	38
e-ISSN	15322157
Journal	European Journal of Surgical Oncology (EJSO)
Language	English
Publisher	Elsevier
Publisher Date	2012-11-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline General Surgery Discipline Oncology Adenocarcinoma Enzymology Ampulla Of Vater Common Bile Duct Neoplasms Pancreatic Neoplasms Thymidylate Synthase Analysis Therapy Adult Aged Aged, 80 And Over Antimetabolites, Antineoplastic Therapeutic Use Tumor Markers, Biological Chemoradiotherapy Female Fluorouracil Humans Male Middle Aged Prognosis Journal Article
Content Type	Text
Resource Type	Article
Subject	Surgery Oncology

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