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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Gastineau, Swellen Viala, Jérôme Caldari, Dominique Mas, Emmanuel Darviot, Estelle Le Gall, Catherine Maurage, Chantal Michaud, Laurent Dabadie, Alain |
| Description | Country affiliation: France Author Affiliation: Gastineau S ( CHU Rennes, Department of Pediatrics, South Hospital, Rennes cedex, France.) |
| Abstract | BACKGROUND: Capsule endoscopy is recommended for children with Peutz-Jeghers syndrome as young as 8 years of age. Aim of our study was to evaluate the contribution of capsule endoscopy in managing risk of further obstructive complications. METHODS: A retrospective analysis of 27 children who received at least 1 capsule endoscopy was conducted. Peutz-Jeghers syndrome was diagnosed based on the presence of an STK11 gene mutation or on the association of a hamartoma with 2 of 3 criteria (family history, mucocutaneous pigmentation, small bowel polyposis). RESULTS: Thirty-seven capsule endoscopies were performed in 27 patients. The median age at first endoscopy was 11.4 years (range, 5.4-20.9). Jejunal polyps were found in 72% and ileal polyps in 55% of capsules. The original recommendations were followed 20/30 times. Three gastroscopies, 4 colonoscopies, 7 double balloon enteroscopies and 1 intra-operative enteroscopy were performed after the capsules. These procedures revealed jejunal polyps in 9/9 cases (8/9 resected) and ileal polyps in 3/5 (all resected). One intussusception occurred 8.4 months after the capsule endoscopy and required surgical resection. CONCLUSION: Capsule endoscopy is easily feasible in Peutz Jeghers syndrome, but the practice of systematic and repeated procedures needs to be validated prospectively. |
| File Format | HTM / HTML |
| ISSN | 15908658 |
| Issue Number | 10 |
| Volume Number | 44 |
| e-ISSN | 18783562 |
| Journal | Digestive and Liver Disease |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-10-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Gastroenterology Capsule Endoscopy Intestinal Polyps Diagnosis Intestine, Small Pathology Peutz-jeghers Syndrome Adolescent Child Child, Preschool Female Follow-up Studies Humans Complications Intussusception Etiology Male Retrospective Studies Young Adult Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hepatology Gastroenterology |
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