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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Paavola, Aku Kurppa, Kalle Ukkola, Anniina Collin, Pekka Lähdeaho, Marja-Leena Huhtala, Heini Mäki, Markku Kaukinen, Katri |
| Description | Country affiliation: Finland Author Affiliation: Paavola A ( School of Medicine, University of Tampere, Tampere, Finland.) |
| Abstract | BACKGROUND: Active serological screening has proved an effective means of increasing the diagnostic rate in celiac disease. The effects of a long-term gluten-free diet on possible gastrointestinal symptoms and psychological well-being in screen-detected patients have nevertheless remained obscure. METHODS: Abdominal symptoms and quality of life were measured in a large cohort of treated screen-detected celiac adults. Comparisons were made with corresponding symptom-detected patients and with non-celiac controls. Dietary adherence was assessed both by structured interview and by serological testing. RESULTS: In both screen- and symptom-detected celiac groups, 88% of the patients were adherent. On a diet, both screen- and symptom-detected patients reported significantly more gastrointestinal symptoms than non-celiac controls. Those screen-detected patients who reported having no symptoms at the time of diagnosis, also remained asymptomatic during the diet. Despite persistent symptoms, psychological well-being in screen-detected patients was comparable with that in non-celiac controls, whereas the symptom-detected patients showed lower quality of life. CONCLUSION: Long-term treated screen-detected celiac patients, especially women, suffer from gastrointestinal symptoms on a gluten free diet similarly to symptom-detected patients. However, despite a similar frequency of persistent symptoms, the quality of life was unimpaired in the screen found, but remained low in the symptom-detected group. |
| File Format | HTM / HTML |
| ISSN | 15908658 |
| Issue Number | 10 |
| Volume Number | 44 |
| e-ISSN | 18783562 |
| Journal | Digestive and Liver Disease |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-10-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Gastroenterology Celiac Disease Mass Screening Quality Of Life Adult Aged Aged, 80 And Over Diagnosis Diet Therapy Psychology Diet, Gluten-free Female Humans Male Middle Aged Patient Compliance Questionnaires Young Adult Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hepatology Gastroenterology |
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