NDLI: Abiraterone- und Cabazitaxel-Härtefallprogramm : Erste klinische Erfahrungen bei Docetaxel-vorbehandelten kastrationsresistenten Prostatakarzinompatienten.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Heck, M. M. Höppner, M. Horn, T. Thalgott, M. Gschwend, J. E. Retz, M.
Description	Author Affiliation: Heck MM ( Urologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Ismaninger Straße 22, 81675 München, Deutschland. m.heck@lrz.tum.de)
Abstract	OBJECTIVE: First clinical experiences with abiraterone and cabazitaxel for the treatment of metastatic castration-resistant prostate cancer patients following docetaxel chemotherapy are reported. PATIENTS AND METHODS: We describe PSA response rates and disease control rates determined by imaging studies at 3 months as well as side effects in the daily routine. All patients were treated within the'compassionate use' programs of cabazitaxel and abiraterone or treated according to their inclusion and exclusion criteria at the 'Technische Universität München'. RESULTS: Of 54 patients, 15 were treated with cabazitaxel and 39 with abiraterone. In patients treated with cabazitaxel, after 3 months of therapy the PSA reduction rate > 50% was 46.2%, the PSA progression rate was 15.4%, and the disease control rate was 83.3%. Main grade 3/4 hematotoxicities were neutropenia (40%) and anemia (20%). Febrile neutropenia was observed in 2 of 15 (13.3%) patients. Main non-hematological grade 3/4 toxicities were diarrhea (13.3%) and polyneuropathy (13.3%). In patients treated with abiraterone, after 3 months of therapy the PSA reduction rate >50% was 35.1%, the PSA progression rate was 46.0%, and the disease control rate was 47.1%. Main grade 3/4 hematotoxicities were anemia (5.1%) and thrombocytopenia (5.1%). Main non-hematological toxicities were fatigue (20.5%), sweating (17.9%), and constipation (10.3%). CONCLUSION: Utilization of cabazitaxel and abiraterone in the daily routine show response rates comparable to their approval studies with acceptable side effects.
File Format	HTM / HTML
ISSN	03402592
Issue Number	3
Volume Number	51
e-ISSN	14330563
Journal	Der Urologe
Language	German
Publisher	Springer
Publisher Date	2012-03-01
Publisher Place	Germany
Access Restriction	Subscribed
Subject Keyword	Discipline Urology Androstenols Administration & Dosage Antineoplastic Combined Chemotherapy Protocols Therapeutic Use Compassionate Use Trials Orchiectomy Prostatic Neoplasms Drug Therapy Taxoids Aged Androstenes Adverse Effects Tumor Markers, Biological Blood Disease Progression Dose-response Relationship, Drug Drug Resistance, Neoplasm Follow-up Studies Humans Male Middle Aged Neoplasm Grading Neoplasm Staging Prednisone Prostate-specific Antigen Pathology Surgery English Abstract Journal Article
Alternative Title	Compassionate use of abiraterone and cabazitaxel: first experiences in docetaxel-pretreated castration-resistant prostate cancer patients
Content Type	Text
Resource Type	Article
Subject	Urology

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