NDLI: Wann soll eine systemische Chemotherapie beim Harnblasenkarzinom eingesetzt werden?

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ohlmann, C-H Stöckle, M.
Description	Author Affiliation: Ohlmann CH ( Klinik für Urologie und Kinderurologie, Universitätsklinikum des Saarlandes, Kirrbergerstraße 1, 66421 Homburg/Saar, Deutschland. Carsten.Ohlmann@uks.eu)
Abstract	The perioperative use of chemotherapy regimens in urinary bladder carcinoma is still under debate. Evidence from clinical trials has not changed over the last decade and therefore current guidelines lack high grade recommendations for the use of perioperative chemotherapy, especially with regard to adjuvant chemotherapy. Neoadjuvant chemotherapy is capable of downsizing locally advanced tumors which leads to better operability. However, the quality of the surgical procedure has a major impact on the risk of recurrence and prognosis of patients and may therefore negatively influence the results of perioperative chemotherapy trials. A number of retrospective studies analyzing the outcome of patients after radical cystectomy have demonstrated that especially patients with node positive bladder carcinoma may benefit from adjuvant chemotherapy. Gemcitabine plus cisplatin still represents the gold standard in the treatment of metastastic bladder carcinoma. Vinflunin has become the standard therapy in second-line treatment and should represent the comparator for further clinical trials in this setting.
File Format	HTM / HTML
ISSN	03402592
Issue Number	3
Volume Number	51
e-ISSN	14330563
Journal	Der Urologe
Language	German
Publisher	Springer
Publisher Date	2012-03-01
Publisher Place	Germany
Access Restriction	Subscribed
Subject Keyword	Discipline Urology Antineoplastic Combined Chemotherapy Protocols Therapeutic Use Neoadjuvant Therapy Urinary Bladder Neoplasms Drug Therapy Chemotherapy, Adjuvant Cisplatin Administration & Dosage Clinical Trials As Topic Combined Modality Therapy Cystectomy Deoxycytidine Analogs & Derivatives Guideline Adherence Humans Lymphatic Metastasis Pathology Neoplasm Invasiveness Neoplasm Staging Prognosis Retrospective Studies Surgery Vinblastine Comparative Study English Abstract Journal Article Review
Alternative Title	When should systemic chemotherapy be used for urinary bladder carcinoma?
Content Type	Text
Resource Type	Article
Subject	Urology

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