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Aldosterone, organ damage and dietary salt.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Catena, Cristiana Colussi, GianLuca Sechi, Leonardo A.
Description	Country affiliation: Italy Author Affiliation: Catena C ( Hypertension Unit, Internal Medicine, Department of Experimental and Clinical Medical Science, University of Udine, Udine, Italy.)
Abstract	Long-term exposure to elevated aldosterone levels or activation of the mineralocorticoid receptors results in cardiac, vascular and renal tissue injury with mechanisms that are independent of blood pressure levels. This evidence has been obtained in experiments carried out in hypertensive animal models, and clinical studies involving patients with heart failure, essential hypertension and primary aldosteronism. Animal studies have shown that aldosterone causes cardiovascular and renal tissue damage only in the context of an inappropriate salt status. It has also been suggested that some of the untoward effects of high-salt intake might depend on activation of mineralocorticoid receptors resulting from increased generation of reactive oxygen species and changes in the intracellular redox potential. Although the interaction between dietary salt intake and circulating aldosterone in causing organ damage has received robust support from the results of animal experiments, the evidence of such interaction in the clinical setting is only preliminary and will require further investigation in appropriately designed studies.
File Format	HTM / HTML
ISSN	03051870
Issue Number	12
Volume Number	40
e-ISSN	14401681
Journal	Clinical and Experimental Pharmacology and Physiology
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2013-12-01
Publisher Place	Australia
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Physiology Discipline Pharmacology Aldosterone Metabolism Cardiovascular Diseases Pathology Heart Ventricles Kidney Sodium Chloride, Dietary Adverse Effects Blood Animals Etiology Prevention & Control Humans Mineralocorticoid Receptor Antagonists Therapeutic Use Receptors, Mineralocorticoid Journal Article Review
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Pharmacology

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Salt in the wound.

Introduction: Aldosterone and salt: heart and kidney.

Renoprotective effects of mineralocorticoid receptor blockade in heminephrectomized (pro)renin receptor transgenic rats.

Trilostane, FAD286, and the role of aldosterone in the central regulation of blood pressure: focus on 'Role of central nervous system aldosterone synthase and mineralocorticoid receptors in salt-induced hypertension in Dahl salt-sensitive rats'.

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Aldosterone, organ damage and dietary salt.