NDLI: Extrarenal roles of the with-no-lysine[K] kinases (WNKs)

Please wait, while we are loading the content...

Molecular insights from dysregulation of the thiazide-sensitive WNK/SPAK/NCC pathway in the kidney: Gordon syndrome and thiazide-induced hyponatraemia

Aldosterone, organ damage and dietary salt.

Mineralocorticoid receptor and cardiac arrhythmia.

Vascular effects of aldosterone: sorting out the receptors and the ligands.

Growth receptor binding protein 10 inhibits glucose-stimulated insulin release from pancreatic ß-cells associated with suppression of the insulin/insulin-like growth factor-1 signalling pathway.

Aberrant Rac1-mineralocorticoid receptor pathways in salt-sensitive hypertension.

Introduction: Aldosterone and salt: heart and kidney.

Roles played by histamine in strenuous or prolonged masseter muscle activity in mice.

Riluzole reduces arrhythmias and myocardial damage induced by coronary occlusion in anaesthetized pigs.

Cerebral open flow microperfusion: a new in vivo technique for continuous measurement of substance transport across the intact blood-brain barrier.

Year: 2013 Volume: 40 Issue: 11

Year: 2013 Volume: 40 Issue: 10

Year: 2013 Volume: 40 Issue: 9

Year: 2013 Volume: 40 Issue: 8

Year: 2013 Volume: 40 Issue: 7

Year: 2013 Volume: 40 Issue: 6

Year: 2013 Volume: 40 Issue: 5

Year: 2013 Volume: 40 Issue: 4

Year: 2013 Volume: 40 Issue: 3

Year: 2013 Volume: 40 Issue: 2

Year: 2013 Volume: 40 Issue: 1

Year: 2012 Volume: 39

Year: 2011 Volume: 38

Year: 2010 Volume: 37

Year: 2009 Volume: 36

Year: 2008 Volume: 35

Year: 1996 Volume: 23

Extrarenal roles of the with-no-lysine[K] kinases (WNKs)

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Siew, Keith O'Shaughnessy, Kevin M.
Description	Country affiliation: United kingdom Author Affiliation: Siew K ( Clinical Pharmacology Unit, Department of Medicine, University of Cambridge, Cambridge, UK.)
Abstract	Identified over a decade ago, the with-no-lysine[K] kinases (WNKs) have been the subsequent focus of intense research into the renal handling of Na(+) , Cl(-) and K(+) and several rare monogenetic diseases. However, the potential extrarenal roles for WNKs have been less well explored. Thiazides and Gordon syndrome are known to have effects on bone mineral density, Ca(2+) and PO4 (3-) homeostasis, which were originally assumed to be an indirect effect through the kidney. However, current data suggest a complex and direct role for WNKs in the physiology of bone. The WNKs also modulate systemic blood pressure at several levels, including the vascular resistance vessels, where they cause vasoconstriction by altering the abundance of the transient receptor potential canonical channel 3 and/or phosphorylation of the Na(+) -K(+) -2Cl(-) cotransporter 1 in vascular smooth muscle cells. The WNKs and many of the cation-coupled Cl(-) cotransporters they regulate are highly expressed in the central nervous system and recent work suggests that WNK dysfunction may have a role in the development of autism, schizophrenia and hereditary sensory and autonomic neuropathy Type 2. Finally, the WNK-sterile 20 kinase signalling axis represents an evolutionarily ancient mechanism for maintaining osmotic homeostasis, but a rapidly expanding body of evidence also shows a role in immunity and cellular regulation.
File Format	HTM / HTML
ISSN	03051870
Issue Number	12
Volume Number	40
e-ISSN	14401681
Journal	Clinical and Experimental Pharmacology and Physiology
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2013-12-01
Publisher Place	Australia
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Physiology Discipline Pharmacology Bone And Bones Enzymology Cardiovascular System Central Nervous System Immune System Intracellular Signaling Peptides And Proteins Physiology Protein-serine-threonine Kinases Autistic Disorder Homeostasis Humans Hypertension Genetics Minor Histocompatibility Antigens Journal Article Research Support, Non-u.s. Gov't Review
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Pharmacology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Mechanisms of type I and type II pseudohypoaldosteronism.

Regulation of ROMK Channel and $K^{+}$ Homeostasis by Kidney-specific WNK1 Kinase

Regulation of WNK1 kinase by extracellular potassium

Tight junction claudins and the kidney in sickness and in health

LINGO-1, WNK1, and EGFR: a hypothesis.

Domains of WNK1 kinase in the regulation of ROMK1.

Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4

Molecular insights from dysregulation of the thiazide-sensitive WNK/SPAK/NCC pathway in the kidney: Gordon syndrome and thiazide-induced hyponatraemia

Hypertension associated polymorphisms in WNK1/WNK4 are not associated with hydrochlorothiazide response.

Extrarenal roles of the with-no-lysine[K] kinases (WNKs)

Similar Documents

Mechanisms of type I and type II pseudohypoaldosteronism.

Regulation of ROMK Channel and $K^{+}$ Homeostasis by Kidney-specific WNK1 Kinase

Regulation of WNK1 kinase by extracellular potassium

Tight junction claudins and the kidney in sickness and in health

LINGO-1, WNK1, and EGFR: a hypothesis.

Domains of WNK1 kinase in the regulation of ROMK1.

Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4

Molecular insights from dysregulation of the thiazide-sensitive WNK/SPAK/NCC pathway in the kidney: Gordon syndrome and thiazide-induced hyponatraemia

Hypertension associated polymorphisms in WNK1/WNK4 are not associated with hydrochlorothiazide response.

Extrarenal roles of the with-no-lysine[K] kinases (WNKs)