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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Eberhardson, Michael Marits, Per Jones, Martina Jones, Petra Karlen, Per Karlsson, Mats Cotton, Graham Woznica, Kerry Maltman, Beatrice Glise, Hans Winqvist, Ola |
| Description | Country affiliation: Sweden Author Affiliation: Eberhardson M ( Department of Medicine, Section of Gastroenterology, Karolinska Institutet, Stockholm, Sweden.) |
| Abstract | Leukapheresis removes circulating leukocytes en route to the target organ. Hitherto unspecific matrixes have been used to remove leukocytes in inflammatory bowel disease (IBD). This report describes a novel selective leukapheresis column based on chemokine-chemokine receptor interaction. We found an increased expression of the gut homing chemokine receptor CCR9 on CD14(+) monocytes and on CD3(+) T lymphocytes from IBD patients. Biologically active CCL25 was coupled to a Sepharose matrix and demonstrated to selectively remove CCR9-expressing cells leaving other cell populations largely unaffected. A patient with active ulcerative colitis, was subjected to CCL25-column leukapheresis. Four days after treatment, he experienced clinical improvement and stable disease improvement ensued. The study illustrates that specific cells can be targeted using high affinity interactions, i.e., CCL25-CCR9 interactions to remove pathogenic gut-homing cells. Leukapheresis using the bCCL25 column should be investigated in a clinical phase I trial of patients with inflammatory bowel disease. |
| File Format | HTM / HTML |
| ISSN | 15216616 |
| Issue Number | 1 |
| Volume Number | 149 |
| e-ISSN | 15217035 |
| Journal | Clinical Immunology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-10-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Immunology Chemokines, Cc Immunology Colitis, Ulcerative Therapy Crohn Disease Leukapheresis Receptors, Ccr Adult Apoptosis Cell Line Cell Proliferation Cytokines Humans Leukocytes, Mononuclear Cytology Male Pilot Projects Young Adult Clinical Trial Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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