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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wang, YaoYao Yang, Yan Luo, YangYang Yin, YongXin Wang, Qing Li, YaPing Kanekura, Takuro Wang, JiuCun Liang, GongPing Zhao, Ming Lu, QianJin Xiao, Rong |
| Description | Country affiliation: China Author Affiliation: Wang Y ( Department of Dermatology, Second Xiangya Hospital, Central South University, 139 Ren-Min Road, Changsha 410011, China.) |
| Abstract | OBJECTIVES: To investigate alterations in histone modifications in B cells and their role in the pathogenesis of systemic sclerosis (SSc). METHODS: Global histone H3/H4 acetylation and H3K4/H3K9 methylation in B cells of SSc were tested by EpiQuik™ assay kits. Related histone modifier enzymes were measured by RT-PCR and Western blot. RESULTS: Global histone H4 hyperacetylation and global histone H3K9 hypomethylation were observed in SSc B cells compared with controls. Expression of JHDM2A was significantly increased but HDAC2, HDAC7, and, SUV39H2 were significantly down-regulated in SSc B cells relative to controls. Global histone H4 acetylation and the expression of HDAC2 were negatively correlated. Global histone H3K9 methylation and the expression of SUV39H2 protein were positively correlated. Global H4 acetylation was positively correlated with disease activity and expression of HDAC2 protein was negatively correlated with skin thickness. CONCLUSIONS: Histone modifications were altered in B cells in SSc correlating with skin thickness and disease activity. |
| File Format | HTM / HTML |
| ISSN | 15216616 |
| Issue Number | 1 |
| Volume Number | 149 |
| e-ISSN | 15217035 |
| Journal | Clinical Immunology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-10-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Immunology B-lymphocytes Metabolism Histones Scleroderma, Systemic Acetylation Adult Female Histone Deacetylase 2 Genetics Histone Deacetylases Histone-lysine N-methyltransferase Humans Jumonji Domain-containing Histone Demethylases Male Methylation Middle Aged Rna, Messenger Pathology Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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