NDLI: Effect of bevacizumab on corneal neovascularization in experimental rabbit model.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ahmed, Abdulgani Berati, Hasanreisoglu Nalan, Akyurek Aylin, Sepici
Description	Country affiliation: Turkey Author Affiliation: Ahmed A ( Department of Ophthalmology, Faculty of Medicine, Gaza University, 23/7 balgat, Ankara, Turkey. drahmmed@gmail.com)
Abstract	PURPOSE: To investigate the effect of bevacizumab in an experimental rabbit model of corneal neovascularization. METHODS: The right eyes of 24 white New Zealand rabbits were included in a corneal neovascularization model using alkaline burn. They were divided into four groups. Topical bevacizumab was installed three times daily in group 1, 5 mg bevacizumab subconjunctivally every 2 days in group 2, 10 mg bevacizumab subconjunctivally every 2 days in group 3 and 0.2 cc of normal saline in the same way in group 4 (control group). All eyes were treated for 7 days. Then the animals were killed and corneal specimens sent for histopathological analysis. Tear film and aqueous humour samples were obtained to assess vascular endothelial growth factor (VEGF) levels. RESULTS: Seven days after topical bevacizumab treatment the neovascular index in group 1 was lower than that in the control group (P = 0.028). In groups 2 and 3 the neovascular index was lower 2 days after subconjunctival bevacizumab treatment than that in control group (P = 0.009 and P = 0.009, respectively). In the control group the VEGF level in aqueous humour increased by 66% from day 7 to 14. In groups 1-3 it decreased by 49.80%, 70.20% and 76.44%, respectively (P = 0.043). The VEGF level in tear film of the control group increased by 35.23% from day 7 to 14, which was not significant (P = 0.893), while in groups 1-3 it decreased by 57.26%, 34.59% and 67.97%, respectively, which was only significant in groups 1 and 3 (P = 0.043). CONCLUSIONS: Subconjunctival 5 mg/mL bevacizumab is effective in reducing corneal neovascularization in animal models and in reducing VEGF levels. Further research is needed to assess the potential side effects and minimal effective dose.
File Format	HTM / HTML
ISSN	14426404
Issue Number	7
Volume Number	37
e-ISSN	14429071
Journal	Clinical & Experimental Ophthalmology
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2009-09-01
Publisher Place	Australia
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Ophthalmology Angiogenesis Inhibitors Administration & Dosage Antibodies, Monoclonal Corneal Neovascularization Drug Therapy Disease Models, Animal Administration, Topical Animals Antibodies, Monoclonal, Humanized Antigens, Cd31 Metabolism Aqueous Humor Bevacizumab Pathology Rabbits Tears Vascular Endothelial Growth Factor A Antagonists & Inhibitors Vitreous Body Journal Article
Content Type	Text
Resource Type	Article
Subject	Ophthalmology

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