NDLI: Relationship between myopia and allergen-specific serum IgE levels in patients with allergic conjunctivitis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mimura, Tatsuya Yamagami, Satoru Usui, Tomohiko Funatsu, Hideharu Noma, Hidetaka Honda, Norihiko Amano, Shiro
Description	Country affiliation: Japan Author Affiliation: Mimura T ( Department of Ophthalmology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan. mimurat-tky@umin.ac.jp)
Abstract	PURPOSE: Various exogenous allergens can cause allergic conjunctivitis, whereas refractive errors are also related (as an endogenous factor) to the pathogenesis of allergic conjunctivitis. However, little is known about the interaction between exogenous and endogenous factors in patients with allergic conjunctivitis. We investigated the relationship between refractive errors and exogenous allergens in patients with allergic conjunctivitis. METHODS: Sixty patients with allergic conjunctivitis and 60 healthy subjects (non-allergy patients) were enrolled. Refraction was carried out in all subjects. In addition, total immunoglobulin E (IgE) and specific IgE levels for 12 inhaled allergens were measured by the capsulated hydrolic carrier polymer system. RESULTS: The patients who were positive for-specific IgE to indoor allergens had higher myopia than those who were negative, including those positive for house dust IgE (-3.66 +/- 2.95 vs. -1.05 +/- 3.39, P = 0.0015), Dermatophagoides pteronyssinus (D. pteronyssinus) IgE (-3.50 +/- 2.91 vs. -1.01 +/- 3.46, P = 0.0021), and acarus IgE (-3.45 +/- 2.21 vs. -1.51 +/- 3.73, P = 0.0087), whereas antibody-positive and antibody-negative patients for outdoor allergens showed no significant differences of refraction. Refractions in indoor group (-3.58 +/- 3.42) and indoor/outdoor (-3.70 +/- 2.64) group were higher than those in outdoor group (-0.84 +/- 2.30, P = 0.0047 and P = 0.0032) and the non-allergy group (-1.30 +/- 1.48, P = 0.0082 and P = 0.0054) [-refraction] was significantly correlated with total IgE (r = 0.333, P = 0.0093), house dust (r = 0.355, P = 0.0054) and D. pteronyssinus (r = 0.379, P = 0.0028), while no correlation between refractive error and outdoor allergens was proven. CONCLUSION: These results suggest that specific IgE levels for indoor allergens, such as house dust, might be associated with refractive errors.
File Format	HTM / HTML
ISSN	14426404
Issue Number	7
Volume Number	37
e-ISSN	14429071
Journal	Clinical & Experimental Ophthalmology
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2009-09-01
Publisher Place	Australia
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Ophthalmology Allergens Immunology Antigens Conjunctivitis, Allergic Immunoglobulin E Blood Myopia Adolescent Adult Animals Antibodies Child Female Humans Male Pyroglyphidae Radioallergosorbent Test Young Adult Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Ophthalmology

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