NDLI: Survival from uveal melanoma in Western Australia 1981-2005.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chew, Avenell L. Spilsbury, Katrina Isaacs, Timothy W.
Spatial Coverage	Western Australia
Description	Country affiliation: Australia Author Affiliation: Chew AL ( Lions Eye Institute, Royal Perth Hospital, Perth, Western Australia, Australia.); Spilsbury K ( Centre for Population Health Research, Curtin University, Curtin, Western Australia, Australia.); Isaacs TW ( Department of Opthalmology, Royal Perth Hospital and Lions Eye Institute, Perth, Western Australia, Australia.)
Abstract	BACKGROUND: The survival rates for patients diagnosed with uveal melanoma in Australia are unknown. Few long-term studies of uveal melanoma are available, and it is unclear whether their results are applicable to the Australian population. DESIGN: Retrospective population-based study. PARTICIPANTS: Patients diagnosed with uveal melanoma between 1981 and 2005 in Western Australia. METHODS: Three hundred eight cases were included. Relative survival and Cox regression were performed. Variables tested for their predictive ability included patient age and sex, tumour-specific variables, and treatment modality. MAIN OUTCOME MEASURES: All-cause survival rates and relative survival rates of patients with diagnosed uveal melanoma. RESULTS: Relative survival rates for the entire cohort were 88.2%, 81.4% and 71.4% at 3, 5 and 10 years, respectively. Predictors of worse survival included mixed-cell tumour morphology (hazard ratio [HR] = 2.1; P-value = 0.002), tumour location at the ciliary body (HR = 1.7; P-value = 0.029) and tumour apical height more than 5 mm (HR 1.9, P-value = 0.026). Of all patients who underwent enucleation, those diagnosed in 1998-2005 died twice as fast (HR = 2.3; P-value = 0.004). In the 17 patients with metastasis, the median survival time from date of diagnosis of metastasis was 3.1 months. CONCLUSIONS: These survival estimates are comparable to those reported for the USA, and more optimistic than those reported for most European-based studies. Tumour apical height, tumour site, tumour morphology and having an enucleation in certain calendar periods of diagnosis were independent predictors of survival. Survival prognosis for patients with diagnosed metastatic uveal melanoma is very poor.
File Format	HTM / HTML
ISSN	14426404
Issue Number	5
Volume Number	43
e-ISSN	14429071
Journal	Clinical & Experimental Ophthalmology
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2015-07-01
Publisher Place	Australia
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Ophthalmology Melanoma Mortality Uveal Neoplasms Adolescent Adult Age Distribution Aged Aged, 80 And Over Antineoplastic Agents Therapeutic Use Brachytherapy Female Humans Male Pathology Therapy Middle Aged Ophthalmologic Surgical Procedures Registries Retrospective Studies Sex Distribution Survival Rate Western Australia Epidemiology Journal Article
Content Type	Text
Resource Type	Article
Subject	Ophthalmology

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