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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Liu, Ning-ning Sun, Yi-zhou Zhao, Ning Chen, Lei |
| Description | Country affiliation: China Author Affiliation: Liu NN ( Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.); Sun YZ ( Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.); Zhao N ( Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.); Chen L ( Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.) |
| Abstract | BACKGROUND: To explore the anti-angiogenesis mechanism of Rofecoxib and determine whether Rofecoxib can be a therapeutic agent for the prevention of retinal neovascularization using a model of retinopathy of prematurity (ROP). METHODS: ROP was induced by exposing mice to 75% oxygen from postnatal day 7 (P7 ) to P12 , then to room air from P12 to P17 . Sixteen mice were in each of the three groups: untreated ROP group as positive control, Rofecoxib-treated ROP group and the normal group (age-matched mice maintained in room air from birth to P17 as negative control). The localized expression of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) protein and mRNA in retinal blood vessels was assessed using immunohistochemistry, Western blot analysis and reverse transcription polymerase chain reaction. RESULTS: Mice in the Rofecoxib-treated group had a significantly reduced retinal neovascular tufts compared with those in the untreated ROP group. COX-2 and VEGF protein and mRNA expression levels were increased in the untreated ROP group, compared with the normal group. Rofecoxib decreased retinal angiogenesis by inhibiting COX-2 and VEGF expression. The expression levels of VEGF and COX-2 were positively correlated at mRNA and protein levels. CONCLUSIONS: COX-2 and VEGF expressions were both involved in the regulation of angiogenesis and had the same cellular localization. Expression of COX-2 correlated positively with VEGF in retinal neovascularization. Rofecoxib attenuated retinal angiogenesis by inhibiting the expression of COX-2 and VEGF mRNA and protein. |
| File Format | HTM / HTML |
| ISSN | 14426404 |
| Issue Number | 5 |
| Volume Number | 43 |
| e-ISSN | 14429071 |
| Journal | Clinical & Experimental Ophthalmology |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2015-07-01 |
| Publisher Place | Australia |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Ophthalmology Cyclooxygenase 2 Inhibitors Therapeutic Use Cyclooxygenase 2 Genetics Disease Models, Animal Gene Expression Regulation Drug Effects Lactones Retinal Neovascularization Prevention & Control Sulfones Vascular Endothelial Growth Factor A Animals Animals, Newborn Blotting, Western Metabolism Immunohistochemistry Mice Mice, Inbred C57bl Rna, Messenger Retinal Vessels Reverse Transcriptase Polymerase Chain Reaction Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ophthalmology |
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