NDLI: Toxoplasma gondii infection blocks the development of allergic airway inflammation in BALB/c mice.

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Toxoplasma gondii infection blocks the development of allergic airway inflammation in BALB/c mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Fenoy, I. Giovannoni, M. Batalla, E. Martin, V. Frank, F. M. Piazzon, I. Goldman, A.
Description	Country affiliation: Argentina Author Affiliation: Fenoy I ( Centro de Estudios en Salud y Medio Ambiente (CESyMA), Escuela de Ciencia y Tecnología, Universidad Nacional de San Martín, Argentina.)
Abstract	There is a link between increased allergy and a reduction of some infections in western countries. Epidemiological data also show that respiratory allergy is less frequent in people exposed to orofaecal and foodborne microbes such as Toxoplasma gondii. Infection with T. gondii induces a strong cell-mediated immunity with a highly polarized T helper type 1 (Th1) response in early stages of infection. Using a well-known murine model of allergic lung inflammation, we sought to investigate whether T. gondii infection could modulate the susceptibility to develop respiratory allergies. Both acute and chronic infection with T. gondii before allergic sensitization resulted in a diminished allergic inflammation, as shown by a decrease in bronchoalveolar lavage (BAL) eosinophilia, mononuclear and eosinophil cell infiltration around airways and vessels and goblet cell hyperplasia. Low allergen-specific immunoglobulin (Ig)E and IgG1 and high levels of allergen-specific IgG2a serum antibodies were detected. A decreased interleukin (IL)-4 and IL-5 production by lymph node cells was observed, while no antigen-specific interferon-gamma increase was detected. Higher levels of the regulatory cytokine IL-10 were found in BAL from infected mice. These results show that both acute and chronic parasite infection substantially blocked development of airway inflammation in adult BALB/c mice. Our results support the hypothesis that T. gondii infection contributes to protection against allergy in humans.
File Format	HTM / HTML
ISSN	00099104
e-ISSN	13652249
DOI	10.1111/j.1365-2249.2008.03813.x
Journal	Clinical & Experimental Immunology
Issue Number	2
Volume Number	155
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2009-02-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Immunology Respiratory Hypersensitivity Prevention & Control Toxoplasmosis Complications Acute Disease Allergens Immunology Animals Bronchoalveolar Lavage Fluid Cytology Cells, Cultured Chronic Disease Cytokines Biosynthesis Eosinophilia Pathology Immunoglobulin E Blood Immunoglobulin G Lung Mice Mice, Inbred Balb C Ovalbumin Th2 Cells Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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