NDLI: Quantitative T cell subsets profile in peripheral blood from patients with idiopathic inflammatory myopathies: tilting the balance towards proinflammatory and pro-apoptotic subsets.

Please wait, while we are loading the content...

Relationship of CD146 expression to secretion of interleukin (IL)-17, IL-22 and interferon-Î³ by CD4(+) T cells in patients with inflammatory arthritis.

Neonatal brain injury and systemic inflammation: modulation by activated protein C ex vivo.

Increased prevalence of MEFV exon 10 variants in Japanese patients with adult-onset Still's disease.

Regulation of the alternative pathway of complement modulates injury and immunity in a chronic model of dextran sulphate sodium-induced colitis.

Generation of ß cell-specific human cytotoxic T cells by lentiviral transduction and their survival in immunodeficient human leucocyte antigen-transgenic mice.

Depletion of regulatory T cells in a hapten-induced inflammation model results in prolonged and increased inflammation driven by T cells.

Human renal tubular epithelial cells suppress alloreactive T cell proliferation.

Defective natural killer cell anti-viral capacity in paediatric HBV infection.

Early dynamics of T helper cell cytokines and T regulatory cells in response to treatment of active Mycobacterium tuberculosis infection.

Species-specific engagement of human nucleotide oligomerization domain 2 (NOD)2 and Toll-like receptor (TLR) signalling upon intracellular bacterial infection: role of Crohn's associated NOD2 gene variants.

Effect of rituximab on B cell phenotype and serum B cell-activating factor levels in patients with thrombotic thrombocytopenic purpura.

Resistin as a potential marker of renal disease in lupus nephritis.

Immune homeostasis, dysbiosis and therapeutic modulation of the gut microbiota.

Quantitative T cell subsets profile in peripheral blood from patients with idiopathic inflammatory myopathies: tilting the balance towards proinflammatory and pro-apoptotic subsets.

Regulatory T cell levels and cytokine production in active non-infectious uveitis: in-vitro effects of pharmacological treatment.

Association of the Smad3 and NFATc2 gene polymorphisms and their serum levels with susceptibility to rheumatoid arthritis in Polish cohorts.

Year: 2015 Volume: 179 Issue: 2

Year: 2015 Volume: 179 Issue: 1

Year: 2014 Volume: 178

Year: 2014 Volume: 177

Year: 2014 Volume: 176

Year: 2014 Volume: 175

Year: 2013 Volume: 174

Year: 2013 Volume: 173

Year: 2012 Volume: 169

Year: 2012 Volume: 168

Year: 2011 Volume: 164

Year: 2010 Volume: 162

Year: 2010 Volume: 161

Year: 2010 Volume: 160

Year: 2010 Volume: 159

Year: 2009 Volume: 158

Year: 2009 Volume: 157

Year: 2009 Volume: 156

Year: 2009 Volume: 155

Year: 2008 Volume: 154

Year: 2008 Volume: 153

Year: 2008 Volume: 152

Year: 2008 Volume: 151

Year: 2007 Volume: 150

Quantitative T cell subsets profile in peripheral blood from patients with idiopathic inflammatory myopathies: tilting the balance towards proinflammatory and pro-apoptotic subsets.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Espinosa-Ortega, F. Gómez-Martin, D. Santana-De Anda, K. Romo-Tena, J. Villaseñor-Ovies, P. Alcocer-Varela, J.
Description	Country affiliation: Mexico Author Affiliation: Espinosa-Ortega F ( Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Mexico City, Mexico.)
Abstract	The role of T cells in idiopathic inflammatory myopathies (IIM) is not yet clear. Some alterations in certain subsets have been reported in inflamed muscle cells. However, a broad quantitative assessment of peripheral T cell subsets has not been evaluated. The aim of this study was to address the quantitative profile of potential pathogenic T cell subsets, namely follicular helper T cells (Tfh), T helper type 17 (Th17), CD28(null) and regulatory T cells (Tregs ) in peripheral blood from IIM patients. Thirty IIM patients and 30 age- and gender-matched healthy donors were included. Peripheral blood mononuclear cells were isolated. T cell subsets were evaluated by flow cytometry, as follows: Tfh (CD4(+) CXCR5(+) ) and its subsets Tfh1 (CXCR3(+) CCR6(-) ), Tfh2 (CXCR3(-) CCR6(-) ), Tfh17 (CXCR3(-) CCR6(+) ), Th17 (CD4(+) IL17A(+) ), CD28(null) (CD4(+) CD28(-) CD244(+) ) and Tregs (CD4(+) CD25(high) forkhead box protein 3 (FoxP3(+) ); CD8(+) CD25(high) FoxP3(+) ). Percentage, absolute numbers and mean fluorescence intensity were analysed. We found increased numbers of total Tfh cells (28 ± 8.16 versus 6.64 ± 1.29, P=0.031) in IIM patients when compared to healthy controls. Moreover, this increment was dependent upon Tfh2 and Tfh17 (Tfh2:9.49 ± 2.19 versus 1.66 ± 0.46, P=0.005; Tfh17 9.48 ± 2.83 versus 1.18 ± 0.21, P=0.014). Also, IIM patients showed higher numbers of Th17 cells (30.25 ± 6.49 versus 13.46 ± 2.95, P=0.031) as well as decreased number of Tregs (5.98 ± 1.61 versus 30.82 ± 8.38, P=0.009). We also found an expansion of CD28(null) cells (162.88 ± 32.29 versus 64 ± 17.35, P=0.015). Our data suggest that IIM patients are characterized by an expansion of peripheral proinflammatory T cells, such as Tfh and Th17, as well as pro-apoptotic CD28 null cells and a deficiency of suppressor populations of Tregs (CD4(+) and CD8(+) ).
File Format	HTM / HTML
ISSN	00099104
e-ISSN	13652249
DOI	10.1111/cei.12475
Journal	Clinical & Experimental Immunology
Issue Number	3
Volume Number	179
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2015-03-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Immunology Inflammation Immunology Muscles Myositis T-lymphocyte Subsets T-lymphocytes, Regulatory Th17 Cells Antigens, Cd Metabolism Apoptosis Forkhead Transcription Factors Homeostasis Immunophenotyping Pathology Receptors, Ccr6 Receptors, Cxcr3 Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Quantitative T cell subsets profile in peripheral blood from patients with idiopathic inflammatory myopathies: tilting the balance towards proinflammatory and pro-apoptotic subsets

Transcriptional profile of tuberculosis antigen-specific T cells reveals novel multifunctional features.

The role of regulatory T cell (Treg) subsets in gestational diabetes mellitus.

Disturbed Th1, Th2, Th17 and T(reg) balance in patients with systemic lupus erythematosus.

Polarization diversity of human CD4+ stem cell memory T cells.

T-cell regulation during viral and nonviral asthma exacerbations.

Low expression of activation marker CD69 and chemokine receptors CCR5 and CXCR3 on memory T cells after 2009 $H_{1}N_{1}$ influenza A antigen stimulation in vitro following H1N1 vaccination of HIV-infected individuals

Human CCR4+ CCR6+ Th17 cells suppress autologous CD8+ T cell responses.

Characterization and functional studies of forkhead box protein 3(-) lymphocyte activation gene 3(+) CD4(+) regulatory T cells induced by mucosal B cells.

Quantitative T cell subsets profile in peripheral blood from patients with idiopathic inflammatory myopathies: tilting the balance towards proinflammatory and pro-apoptotic subsets.

Similar Documents

Quantitative T cell subsets profile in peripheral blood from patients with idiopathic inflammatory myopathies: tilting the balance towards proinflammatory and pro-apoptotic subsets

Transcriptional profile of tuberculosis antigen-specific T cells reveals novel multifunctional features.

The role of regulatory T cell (Treg) subsets in gestational diabetes mellitus.

Disturbed Th1, Th2, Th17 and T(reg) balance in patients with systemic lupus erythematosus.

Polarization diversity of human CD4+ stem cell memory T cells.

T-cell regulation during viral and nonviral asthma exacerbations.

Low expression of activation marker CD69 and chemokine receptors CCR5 and CXCR3 on memory T cells after 2009 $H_{1}N_{1}$ influenza A antigen stimulation in vitro following H1N1 vaccination of HIV-infected individuals

Human CCR4+ CCR6+ Th17 cells suppress autologous CD8+ T cell responses.

Characterization and functional studies of forkhead box protein 3(-) lymphocyte activation gene 3(+) CD4(+) regulatory T cells induced by mucosal B cells.

Quantitative T cell subsets profile in peripheral blood from patients with idiopathic inflammatory myopathies: tilting the balance towards proinflammatory and pro-apoptotic subsets.