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IL-5 production by resident mucosal allergen-specific T cells in an explant model of allergic rhinitis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Skrindo, I. Ballke, C. Gran, E. Johansen, F-E Baekkevold, E. S. Jahnsen, F. L.
Description	Country affiliation: Norway Author Affiliation: Skrindo I ( Department of Pathology and Centre for Immune Regulation, Oslo University Hospital and University of Oslo, Oslo, Norway.); Ballke C ( Department of Otorhinolaryngology, Akershus University Hospital, Lørenskog, Norway.); Gran E ( Department of Pathology and Centre for Immune Regulation, Oslo University Hospital and University of Oslo, Oslo, Norway.); Johansen FE ( Department of Otolaryngology, Lovisenberg Diakonale Hospital, Oslo, Norway.); Baekkevold ES ( Department of Pathology and Centre for Immune Regulation, Oslo University Hospital and University of Oslo, Oslo, Norway.); Jahnsen FL ( Department of Pathology and Centre for Immune Regulation, Oslo University Hospital and University of Oslo, Oslo, Norway.)
Abstract	BACKGROUND: Seasonal allergic rhinitis is a chronic inflammation in the nasal mucosa triggered by inhaled aeroallergens. The inflammatory reaction is controlled by allergen-specific T cells, but where and how these T cells become activated is not fully understood. OBJECTIVES: We wanted to determine whether allergen-specific T-helper (Th) 2 cells are residing in the nasal mucosa under steady-state conditions outside of the pollen season and, if so, whether these cells are activated locally in response to allergen challenge. METHODS: Mucosal biopsies from the lower turbinate were obtained out of season from patients with either birch- or grass-pollen-allergic rhinitis and from healthy controls. Cultured explant samples were challenged with relevant pollen extract or with a mix of overlapping 20-mer peptides derived from the sequence of the major birch allergen, Betula verrucosa (Bet v) 1. After 24 h, culture medium was harvested for multiplex cytokine and tryptase analysis. RESULTS: Significant amounts of interleukin (IL)-5 were secreted from resident cells in response to ex vivo allergen challenge in the allergic group only. No increase was observed for the other cytokines measured. Production of IL-5 in response to both extract and the Bet v1-derived peptide mix strongly suggested that T cells were a major source of IL-5. CONCLUSION: Our explant model indicated that local presentation of antigen to resident allergen-specific Th2 cells is the early event in the pathogenesis of allergic rhinitis. These findings identify possible cellular targets for anti-inflammatory treatment.
File Format	HTM / HTML
ISSN	09547894
Issue Number	8
Volume Number	45
e-ISSN	13652222
Journal	Clinical & Experimental Allergy
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2015-08-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Immunology Antigens, Plant Immunology Interleukin-5 Models, Immunological Nasal Mucosa Rhinitis, Allergic Th2 Cells Adolescent Adult Child Female Humans Male Pathology Tissue Culture Techniques Journal Article
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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IL-5 production by resident mucosal allergen-specific T cells in an explant model of allergic rhinitis.