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The Editor takes a closer look at some of this month's articles.

Year: 2015 Volume: 45 Issue: 7

Year: 2015 Volume: 45 Issue: 6

Year: 2015 Volume: 45 Issue: 5

Year: 2015 Volume: 45 Issue: 4

Year: 2015 Volume: 45 Issue: 3

Year: 2015 Volume: 45 Issue: 2

Year: 2015 Volume: 45 Issue: 1

Year: 2014 Volume: 44

Year: 2013 Volume: 43

Year: 2012 Volume: 42

Year: 2011 Volume: 41

Year: 2010 Volume: 40

Year: 2009 Volume: 39

Year: 2008 Volume: 38

Airway responses towards allergens - from the airway epithelium to T cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Papazian, D. Hansen, S. Würtzen, P. A.
Description	Country affiliation: Denmark Author Affiliation: Papazian D ( Department of Cancer & Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.); Hansen S ( ALK, Hørsholm, Denmark.); Würtzen PA ( Department of Cancer & Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.)
Abstract	The prevalence of allergic diseases such as allergic rhinitis is increasing, affecting up to 30% of the human population worldwide. Allergic sensitization arises from complex interactions between environmental exposures and genetic susceptibility, resulting in inflammatory T helper 2 (Th2) cell-derived immune responses towards environmental allergens. Emerging evidence now suggests that an epithelial dysfunction, coupled with inherent properties of environmental allergens, can be responsible for the inflammatory responses towards allergens. Several epithelial-derived cytokines, such as thymic stromal lymphopoietin (TSLP), IL-25 and IL-33, influence tissue-resident dendritic cells (DCs) as well as Th2 effector cells. Exposure to environmental allergens does not elicit Th2 inflammatory responses or any clinical symptoms in nonatopic individuals, and recent findings suggest that a nondamaged, healthy epithelium lowers the DCs' ability to induce inflammatory T-cell responses towards allergens. The purpose of this review was to summarize the current knowledge on which signals from the airway epithelium, from first contact with inhaled allergens all the way to the ensuing Th2-cell responses, influence the pathology of allergic diseases.
File Format	HTM / HTML
ISSN	09547894
Issue Number	8
Volume Number	45
e-ISSN	13652222
Journal	Clinical & Experimental Allergy
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2015-08-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Immunology Allergens Immunology Cytokines Dendritic Cells Respiratory Mucosa Rhinitis, Allergic Th2 Cells Animals Pathology Humans Journal Article Review
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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