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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kim, K. H. Jeung, K. J. Kim, H. J. Bae, S. B. Kim, C. K. Lee, N. S. Lee, K. T. Park, S. K. Won, J. H. Hong, D. S. Park, H. S. |
| Description | Responsible library: WPRO |
| Abstract | PURPOSE: Palliative chemotherapy for patients with recurrent or metastatic gastric cancer has been shown to have a survival benefit. Docetaxel monotherapy has achieved appreciable results for treating gastric cancer. We investigated the clinical efficacy and feasibility of a docetaxel and cisplatin combination regimen for patients suffering with recurrent or metastatic gastric cancer. MATERIALS AND METHODS: Patients with histologically proven, bidimensionally measurable lesions of recurrent or metastatic gastric cancer, and they had an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2 and no prior palliative chemotherapy were eligible for this study. The combination chemotherapy regimen consisted of docetaxel 75 mg/m2 plus cisplatin 75 mg/m2 on day 1, and this was repeated every 3 weeks until disease progression. RESULTS: 32 patients were enrolled from 2002 to 2005. The objective response rate was 31.3% (95% confidenceinterval (CI): 14.2~48.2%) with no CR. The disease control rate was 59.4%. At a median follow up of 38.9 months, the median overall survival was 7.4 months (95% CI: 6.3~8.5). The median time to progression was 4.7 months (95% CI: 3.1~6.3). During a total of 106 cycles, grade 3 or 4 hematological toxicities were observed as follows: neutropenia (39 of 106 cycles) and anemia (3 of 106 cycles). The grade 3 or 4 non-hematological toxicities included anorexia (18.9%) and nausea/vomiting (21.7%).CONCLUSION: Docetaxel and cisplatin combination chemotherapy showed promising anti-tumor activity and this was well tolerated as a first-line treatment for patients with recurrent or metastatic gastric cancer. Further large, randomized phase III studies are warranted. |
| File Format | HTM / HTML |
| ISSN | 15982998 |
| e-ISSN | 20059256 |
| Journal | Cancer Research and Treatment |
| Issue Number | 2 |
| Volume Number | 39 |
| Language | English |
| Publisher | Korean Cancer Association. |
| Publisher Date | 2007-01-01 |
| Publisher Place | Korea (South) |
| Access Restriction | Open |
| Subject Keyword | Discipline Neoplasms Docetaxel Cisplatin Chemotherapy-oncologic Procedure Gastric Cancer Stage Iv Nos Median Statistical Measurement |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
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