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A serological survey for antibodies against foot-and-mouth disease virus (FMDV) in domestic pigs during outbreaks in Kenya.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wekesa, Sabenzia N. Namatovu, Alice Sangula, Abraham K. Dhikusooka, Moses T. Muwanika, Vincent B. Tjørnehøj, Kirsten
Spatial Coverage	Kenya
Description	Author Affiliation: Wekesa SN ( Foot-and-Mouth Disease Laboratory, Embakasi, P.O. Box 18021, 00500, Nairobi, Kenya, snabalayo@yahoo.com.)
Abstract	Foot-and-mouth disease (FMD) is endemic in Kenya and has been well studied in cattle, but not in pigs, yet the role of pigs is recognised in FMD-free areas. This study investigated the presence of antibodies against FMD virus (FMDV) in pigs sampled during a countrywide random survey for FMD in cattle coinciding with SAT 1 FMDV outbreaks in cattle. A total of 191 serum samples were collected from clinically healthy pigs in 17 districts. Forty-two of the 191 sera were from pigs vaccinated against serotypes O/A/SAT 2 FMDV. Antibodies against FMDV non-structural proteins were found in sera from 30 vaccinated and 71 non-vaccinated pigs, altogether 101/191 sera (53 %), and 91 % of these (92/101) also had antibodies measurable by serotype-specific ELISAs, predominantly directed against SAT 1 with titres of 10-320. However, only five high titres against SAT 1 in vaccinated pigs were confirmed by virus neutralisation test (VNT). Due to high degree of agreement between the two ELISAs, it was concluded that positive pigs had been infected with FMDV. Implications of these results for the role of pigs in the epidemiology of FMD in Kenya are discussed, and in-depth studies are recommended.
File Format	HTM / HTML
ISSN	00494747
Issue Number	3
Volume Number	46
e-ISSN	15737438
Journal	Tropical Animal Health and Production
Language	English
Publisher	Springer
Publisher Date	2014-03-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Veterinary Medicine Discipline Tropical Medicine Foot-and-mouth Disease Virus Immunology Foot-and-mouth Disease Epidemiology Swine Diseases Animals Antibodies, Viral Blood Cattle Cattle Diseases Disease Outbreaks Veterinary Enzyme-linked Immunosorbent Assay Kenya Neutralization Tests Seroepidemiologic Studies Serologic Tests Swine Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Animal Science and Zoology Food Animals

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