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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Maddur, Mohan S. Mohan, M. S. Gajendragad, M. R. Kishore, Subodh Gopalakrishna, S. Singh, Nem |
| Description | Country affiliation: India Author Affiliation: Maddur MS ( Indian Veterinary Research Institute, Bangalore, Karnataka, India.) |
| Abstract | Humoral and mucosal (secretory antibody)immune response to FMDV type Asia 1 in cattle was analyzed after vaccination and infection using virus neutralizing test (VNT). Vaccination (1/16th the usual dose) failed to protect cattle from generalized clinical disease following experimental FMDV Asia 1 infection. Our results showed that infection induced higher and prolonged serum antibody titres indicating antigen mass is important for optimal immune response. Experimental FMDV infection induced significant secretory antibody (mucosal) response in cattle. Though, there was no difference in the serum antibody response between the cattle that developed generalized infection (unprotected) and those with only localized infection (protected), secretory antibody response differed, wherein the unprotected cattle had higher secretory response than protected cattle. Thus, FMDV Asia 1 infection stimulates a similar serum antibody response and a unique secretory antibody response among the infected cattle. |
| File Format | HTM / HTML |
| ISSN | 01657380 |
| Issue Number | 2 |
| Volume Number | 33 |
| e-ISSN | 15737446 |
| Journal | Veterinary Research Communications |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2009-02-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Veterinary Medicine Cattle Diseases Immunology Virology Foot-and-mouth Disease Virus Foot-and-mouth Disease Animals Antibodies, Viral Blood Cattle Prevention & Control Female Immunity, Mucosal Male Neutralization Tests Veterinary Saliva Statistics, Nonparametric Vaccination Viral Vaccines Administration & Dosage Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Veterinary Medicine |
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