NDLI: Practical barriers to delivering autologous bone marrow stem cell therapy as an adjunct to liver resection.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Stutchfield, Benjamin M. Rashid, Sameena Forbes, Stuart J. Wigmore, Stephen J.
Description	Country affiliation: United kingdom Author Affiliation: Stutchfield BM ( Medical Research Council Centre for Inflammation Research and Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom. benstutch@aol.com)
Abstract	Liver resection has been associated with significant morbidity and mortality due to hepatic dysfunction or hepatic failure in the postoperative period. Autologous bone marrow stem cell (BMSC) therapy may offer the potential to enhance hepatic regeneration in this setting, perhaps increasing the safety of the procedure. Preclinical models and initial translational studies have suggested that autologous BMSC administration can facilitate hepatic regeneration following both acute and chronic liver disease. While translational studies have begun in chronic hepatic disease, translation to hepatic surgical indications has been limited. This review explores the practical barriers currently restricting the delivery of autologous stem cell therapies to enhance hepatic regeneration following liver resection including selection of cell type, cell isolation, therapy delivery, trial design, and assessment of efficacy.
File Format	HTM / HTML
ISSN	15473287
Issue Number	2
Volume Number	19
e-ISSN	15578534
Journal	Stem Cells and Development
Language	English
Publisher	Mary Ann Liebert, Inc.
Publisher Date	2010-02-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Discipline Cell Biology Discipline Hematology Bone Marrow Transplantation Methods Liver Diseases Physiopathology Surgery Liver Regeneration Animals Clinical Trials As Topic Hepatectomy Humans Transplantation, Autologous Treatment Outcome Journal Article Review
Content Type	Text
Resource Type	Article
Subject	Cell Biology Developmental Biology Hematology

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